T. J. Murphy

TL;DR: It is demonstrated that skeletal muscle cells express functionally active NF-AT proteins and that the nuclear translocation of individual NF- AT isoforms, which is essential for the ability to coordinate gene expression, is influenced markedly by the differentiation state of the muscle cell.

TL;DR: Examination of the expression and activation of protease activated receptors (PARs), lysophosphatidic acid (LPA) receptors, and sphingosine-1-phosphate (S1P) receptors on murine astrocytes shows that activation of these three receptor classes can lead to astrogliosis in vivo and proliferation of astroCytes in vitro.

TL;DR: Results indicate that ANG II down-regulates its vascular receptor by both transcriptional and post-transcriptional mechanisms, which may participate in the coordinated physiological adaptation of vascular tone to vasoactive hormones.

TL;DR: Human mtTrx is a member of the thioredoxin family of proteins localized to mitochondria and may play important roles in protection against oxidant-induced apoptosis.

TL;DR: The results suggest that, although functional Runx2 is essential to multiple osteoblast‐specific activities, in vitro matrix mineralization requires additional tissue‐specific cofactors, which supplement Runx1 activity.