J
Jonathan Gephart
Researcher at Vanderbilt University
Publications - 5
Citations - 906
Jonathan Gephart is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Skeletal muscle & NFAT. The author has an hindex of 5, co-authored 5 publications receiving 842 citations. Previous affiliations of Jonathan Gephart include Emory University & Vanderbilt University Medical Center.
Papers
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Journal ArticleDOI
Amphiregulin Exosomes Increase Cancer Cell Invasion
James N. Higginbotham,Michelle Demory Beckler,Jonathan Gephart,Jeffrey L. Franklin,Galina Bogatcheva,Gert-Jan Kremers,David W. Piston,Gregory D. Ayers,Russell E. McConnell,Matthew J. Tyska,Robert J. Coffey,Robert J. Coffey +11 more
TL;DR: It is speculated that EGFR ligand signaling via exosomes might contribute to diverse cancer phenomena such as field effect and priming of the metastatic niche.
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Regulation of the growth of multinucleated muscle cells by an NFATC2-dependent pathway.
Valerie Horsley,Bret B. Friday,Sarah Matteson,Kristy M. Kegley,Jonathan Gephart,Grace K. Pavlath +5 more
TL;DR: It is demonstrated that during growth of multinucleated muscle cells, myoblasts initially fuse to form myotubes with a limited number of nuclei and that subsequent nuclear addition and increases in myotube size are controlled by a molecular pathway regulated by NFATC2.
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Systemic administration of the NF-κB inhibitor curcumin stimulates muscle regeneration after traumatic injury
TL;DR: It is shown that the kinetics and extent of muscle regeneration in vivo after trauma are greatly enhanced following systemic administration of curcumin, a pharmacological inhibitor of the transcription factor NF-κB, and that modulation of NF-σB activity within muscle tissue is beneficial for muscle repair.
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Altered primary myogenesis in NFATC3(-/-) mice leads to decreased muscle size in the adult.
TL;DR: A heretofore unknown role for the transcription factor NFAT in early skeletal muscle development is suggested, suggesting a role for NFATC3 during early events in primary myogenesis.
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Identification of a novel mono-leucine basolateral sorting motif within the cytoplasmic domain of amphiregulin.
Jonathan Gephart,Bhuminder Singh,James N. Higginbotham,Jeffrey L. Franklin,Jeffrey L. Franklin,Alfonso González,Heike Fölsch,Robert J. Coffey,Robert J. Coffey +8 more
TL;DR: The results show that recycling, but not delivery, of AREG to the BL surface is AP‐1B dependent, and identifies a novel BL sorting motif consisting of a single leucine C‐terminal to an acidic cluster (EEXXXL).