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Brett A. Wagner
Researcher at University of Iowa
Publications - 90
Citations - 4585
Brett A. Wagner is an academic researcher from University of Iowa. The author has contributed to research in topics: Oxidative stress & Pancreatic cancer. The author has an hindex of 37, co-authored 81 publications receiving 3889 citations. Previous affiliations of Brett A. Wagner include University of Northern Iowa & Roy J. and Lucille A. Carver College of Medicine.
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Journal ArticleDOI
Free Radical-Mediated Lipid Peroxidation in Cells: Oxidizability Is a Function of Cell Lipid bis-Allylic Hydrogen Content
TL;DR: The quantitative results clearly demonstrate, for the first time, that the number of bis-allylic positions contained in the cellular lipids of intact cells determines their susceptibility, i.e., oxidizability, to free radical-mediated peroxidative events.
Journal ArticleDOI
O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate
Joshua D. Schoenfeld,Zita A. Sibenaller,Kranti A. Mapuskar,Brett A. Wagner,Kimberly L. Cramer-Morales,Muhammad Furqan,Sonia Sandhu,Thomas L. Carlisle,Mark C. Smith,Taher Abu Hejleh,Daniel J. Berg,Jun Zhang,John Keech,Kalpaj R. Parekh,Sudershan K. Bhatia,Varun Monga,Kellie L. Bodeker,Logan Ahmann,Sandy Vollstedt,Heather Brown,Erin P. Shanahan Kauffman,Mary E. Schall,Raymond J. Hohl,Gerald H. Clamon,Jeremy D.W. Greenlee,Matthew A. Howard,Michael K. Schultz,Brian J. Smith,Dennis P. Riley,Frederick E. Domann,Joseph J. Cullen,Garry R. Buettner,John M. Buatti,Douglas R. Spitz,Bryan G. Allen +34 more
TL;DR: It is shown that alterations in cancer cell mitochondrial oxidative metabolism resulting in increased levels of O2⋅- and H2O2 are capable of disrupting intracellular iron metabolism, thereby selectively sensitizing non-small-cell lung cancer and glioblastoma cells to ascorbate through pro-oxidant chemistry involving redox-active labile iron and H 2O2.
Journal ArticleDOI
The rate of oxygen utilization by cells.
TL;DR: The discovery of oxygen is considered by some to be the most important scientific discovery of all time--from both physical-chemical/astrophysics and biology/evolution viewpoints.
Journal ArticleDOI
Mechanisms of Ascorbate-Induced Cytotoxicity in Pancreatic Cancer
Juan Du,Sean M. Martin,Mark Levine,Brett A. Wagner,Garry R. Buettner,Sih-han Wang,Agshin F. Taghiyev,Changbin Du,Charles M. Knudson,Joseph J. Cullen +9 more
TL;DR: Results show that pharmacologic doses of ascorbate, easily achievable in humans, may have potential for therapy in pancreatic cancer and induced a caspase-independent cell death that was associated with autophagy.
Journal ArticleDOI
Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial
J. L. Welsh,Brett A. Wagner,T. J. van’t Erve,Pamela Zehr,Daniel J. Berg,Daniel J. Berg,Thorvardur R. Halfdanarson,Thorvardur R. Halfdanarson,Nelson S. Yee,K. L. Bodeker,Juan Du,L. J. Roberts,Jeanne Drisko,Mark Levine,Garry R. Buettner,Garry R. Buettner,Joseph J. Cullen,Joseph J. Cullen,Joseph J. Cullen +18 more
TL;DR: Initial data suggest pharmacologic ascorbate administered concurrently with gemcitabine is well tolerated and some efficacy is suggested from this small sampling, and further studies powered to determine efficacy should be conducted.