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Douglas R. Spitz
Researcher at University of Iowa
Publications - 338
Citations - 24125
Douglas R. Spitz is an academic researcher from University of Iowa. The author has contributed to research in topics: Oxidative stress & Glutathione. The author has an hindex of 77, co-authored 307 publications receiving 21410 citations. Previous affiliations of Douglas R. Spitz include Hashemite University & Washington University in St. Louis.
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Journal ArticleDOI
A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation
Jeffrey R. Erickson,Mei Ling A. Joiner,Xiaoqun Guan,William Kutschke,Jinying Yang,Carmine V. Oddis,Ryan K. Bartlett,John S. Lowe,Susan E. O'Donnell,Nukhet Aykin-Burns,Matthew C. Zimmerman,Kathy Zimmerman,Amy-Joan L. Ham,Robert M. Weiss,Douglas R. Spitz,Madeline A. Shea,Roger J. Colbran,Peter J. Mohler,Mark E. Anderson +18 more
TL;DR: It is shown that oxidation of paired regulatory domain methionine residues sustains CaMKII activity in the absence of Ca2+/CaM and highlights the critical importance of oxidation-dependent CaMK II activation to AngII and ischemic myocardial apoptosis.
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Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress
Randa Tao,Mitchell C. Coleman,J. Daniel Pennington,Özkan Özden,Seong Hoon Park,Haiyan Jiang,Hyun Seok Kim,Charles R. Flynn,Salisha Hill,W. Hayes McDonald,Alicia K. Olivier,Douglas R. Spitz,David Gius +12 more
TL;DR: Infestation of Sirt3⁻/⁻ MEFs with lenti-MnSOD(K122-R) inhibited in vitro immortalization by an oncogene (Ras), inhibited IR-induced genomic instability, and decreased mitochondrial superoxide, suggesting acetylation directly regulates function.
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SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress
Hyun-Seok Kim,Krish Patel,Kristi Muldoon-Jacobs,Kheem S. Bisht,Nukhet Aykin-Burns,J. Daniel Pennington,Riet van der Meer,Phuongmai Nguyen,Jason E. Savage,Kjerstin M. Owens,Athanassios Vassilopoulos,Özkan Özden,Seong Hoon Park,Keshav K. Singh,Sarki A. Abdulkadir,Douglas R. Spitz,Chu-Xia Deng,David Gius +17 more
TL;DR: These results identify SIRT3 as a genomically expressed, mitochondria-localized tumor suppressor and human breast and other human cancer specimens exhibit reduced Sirt3 levels.
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An assay for superoxide dismutase activity in mammalian tissue homogenates.
TL;DR: The inclusion of BCS in the NBT assay system was shown to make the accurate measurement of SOD activity in tissues with interferences possible, and the most effective compounds were metal chelators that were also electron transport chain inhibitors.
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Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology.
TL;DR: Evidence supporting the concept that perturbations in intracellular metabolic oxidation/reduction reactions contribute to the biological effects of radiation exposure is focused on as well as new concepts emerging from the field of free radical biology that may be relevant to future studies in radiobiology.