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Brett T. Marck
Researcher at Veterans Health Administration
Publications - 57
Citations - 3857
Brett T. Marck is an academic researcher from Veterans Health Administration. The author has contributed to research in topics: Prostate cancer & Testosterone. The author has an hindex of 26, co-authored 56 publications receiving 3510 citations. Previous affiliations of Brett T. Marck include Fred Hutchinson Cancer Research Center & United States Department of Veterans Affairs.
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Journal ArticleDOI
Resistance to CYP17A1 inhibition with abiraterone in castration resistant prostate cancer: Induction of steroidogenesis and androgen receptor splice variants
Elahe A. Mostaghel,Brett T. Marck,Stephen R. Plymate,Robert L. Vessella,Stephen P. Balk,Alvin M. Matsumoto,Peter S. Nelson,R. Bruce Montgomery +7 more
TL;DR: It is indicated that abiraterone reduces CRPC growth via suppression of intratumoral androgens and that resistance to abIRaterone may occur through mechanisms that include upregulation of CYP17A1, and/or induction of AR and AR splice variants that confer ligand-independent AR transactivation.
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Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice
Marzia Scortegagna,Kan Ding,Yavuz Oktay,Arti Gaur,Frederick A. Thurmond,Liang-Jun Yan,Brett T. Marck,Alvin M. Matsumoto,John M. Shelton,James A. Richardson,Michael J. Bennett,Michael J. Bennett,Joseph A. Garcia +12 more
TL;DR: A rheostat role for HIF-2α is proposed that allows for the maintenance of ROS as well as mitochondrial homeostasis and avoids multiple-organ pathology, biochemical abnormalities and altered gene expression patterns in mice lacking this family member.
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Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors.
Changmeng Cai,Sen Chen,Patrick R Ng,Glenn J. Bubley,Peter S. Nelson,Elahe A. Mostaghel,Brett T. Marck,Alvin M. Matsumoto,Nicholas I. Simon,Hongyun Wang,Shaoyong Chen,Steven P. Balk +11 more
TL;DR: It is reported that AR activity in castration-resistant VCaP tumor xenografts can be restored through CYP17A1-dependent de novo androgen synthesis, and that abiraterone treatment of these xenografteds imposes selective pressure for increased intratumoral expression of CYP 17A1, thereby generating a mechanism for development of resistance to CYP16A1 inhibitors.
Journal ArticleDOI
Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice.
Mark S. Szczypka,Keith Kwok,Michelle D. Brot,Brett T. Marck,Alvin M. Matsumoto,Brian A. Donahue,Richard D. Palmiter +6 more
TL;DR: A fundamental difference exists between feeding for sustenance and the ability to prefer rewarding substances, and replacement of DA to either region restores preference for sucrose or a palatable diet without fully rescuing coordination or initiation of movement.
Journal ArticleDOI
Feeding behavior in dopamine-deficient mice
Mark S. Szczypka,Mark A. Rainey,Douglas S. Kim,William A. Alaynick,Brett T. Marck,Alvin M. Matsumoto,Richard D. Palmiter +6 more
TL;DR: The feeding and locomotor responses of DA-deficient (DA-/-) mice to 3, 4-dihyroxy-L-phenylalanine (L-DOPA) were characterized to investigate the relationship between brain DA levels and these complex behaviors.