P
Patrick R Ng
Researcher at Harvard University
Publications - 2
Citations - 416
Patrick R Ng is an academic researcher from Harvard University. The author has contributed to research in topics: Dehydroepiandrosterone & Androgen deprivation therapy. The author has an hindex of 1, co-authored 2 publications receiving 376 citations.
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Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors.
Changmeng Cai,Sen Chen,Patrick R Ng,Glenn J. Bubley,Peter S. Nelson,Elahe A. Mostaghel,Brett T. Marck,Alvin M. Matsumoto,Nicholas I. Simon,Hongyun Wang,Shaoyong Chen,Steven P. Balk +11 more
TL;DR: It is reported that AR activity in castration-resistant VCaP tumor xenografts can be restored through CYP17A1-dependent de novo androgen synthesis, and that abiraterone treatment of these xenografteds imposes selective pressure for increased intratumoral expression of CYP 17A1, thereby generating a mechanism for development of resistance to CYP16A1 inhibitors.
Surgical advances in the management of brain metastases.
TL;DR: For example, in this paper, the authors proposed keyhole craniotomies and tubular retractors to optimize the preservation of normal parenchyma without compromising the extent of resection.