B
Brian Hutzen
Researcher at Nationwide Children's Hospital
Publications - 35
Citations - 1543
Brian Hutzen is an academic researcher from Nationwide Children's Hospital. The author has contributed to research in topics: Oncolytic virus & Cancer. The author has an hindex of 19, co-authored 34 publications receiving 1327 citations. Previous affiliations of Brian Hutzen include The Research Institute at Nationwide Children's Hospital & Ohio State University.
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Journal ArticleDOI
Novel STAT3 Phosphorylation Inhibitors Exhibit Potent Growth-Suppressive Activity in Pancreatic and Breast Cancer Cells
Li Lin,Brian Hutzen,Mingxin Zuo,Sarah Ball,Stephanie Deangelis,Elizabeth Foust,Bulbul Pandit,Michael A. Ihnat,Satyendra S. Shenoy,Samuel K. Kulp,Pui-Kai Li,Chenglong Li,James R. Fuchs,Jiayuh Lin +13 more
TL;DR: FLLL31 and FLLL32 are effective inhibitors of STAT3 phosphorylation, DNA-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines.
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A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.
Li Lin,Brian Hutzen,Pui-Kai Li,Sarah Ball,Mingxin Zuo,Stephanie Deangelis,Elizabeth Foust,Matthew Sobo,Lauren Friedman,Deepak Bhasin,Ling Cen,Ling Cen,Chenglong Li,Jiayuh Lin +13 more
TL;DR: Results indicate that LLL12 may be a potential therapeutic agent for human cancer cells expressing constitutive STAT3 signaling and demonstrates a potent inhibitory activity on breast and glioblastoma tumor growth in a mouse xenograft model.
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Signal transducer and activator of transcription 3 activation is associated with bladder cancer cell growth and survival
Chun Liang Chen,Chun Liang Chen,Ling Cen,Jennifer Kohout,Brian Hutzen,Christina Chan,Fu Chuan Hsieh,Fu Chuan Hsieh,Abbey Loy,Victor Huang,Victor Huang,Gong Cheng,Gong Cheng,Jiayuh Lin +13 more
TL;DR: Interference of Stat3 signaling pathway emerges as a potential therapeutic approach for bladder cancer as down-regulation of anti-apoptotic genes and a cell cycle regulating gene was associated with the cell growth inhibition and apoptosis.
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LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model
Beng Fuh,Matthew Sobo,Cen L,Josiah D,Brian Hutzen,Katryna Cisek,Deepak Bhasin,Nicholas Regan,Li Lin,Chan C,Caldas H,Stephanie Deangelis,Chenglong Li,Pui-Kai Li,Jiayuh Lin +14 more
TL;DR: The results suggest that LLL-3 may be a potential therapeutic agent in the treatment of glioblastoma with constitutive STAT3 activation with prolonged survival relative to vehicle-treated mice.
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STAT3 can be activated through paracrine signaling in breast epithelial cells
Jacqueline Lieblein,Sarah Ball,Brian Hutzen,A. Kate Sasser,Huey Jen Lin,Tim H M Huang,Brett Hall,Jiayuh Lin +7 more
TL;DR: These results demonstrate STAT3 phosphorylation in breast epithelial cells can be stimulated by paracrine signaling through soluble factors from both breast cancer cells and breast cancer associated fibroblasts with elevated p-STAT3 phosphate levels.