J
Jiayuh Lin
Researcher at The Research Institute at Nationwide Children's Hospital
Publications - 88
Citations - 6224
Jiayuh Lin is an academic researcher from The Research Institute at Nationwide Children's Hospital. The author has contributed to research in topics: STAT3 & Phosphorylation. The author has an hindex of 44, co-authored 83 publications receiving 5789 citations. Previous affiliations of Jiayuh Lin include University of Michigan & Ohio State University.
Papers
More filters
Journal ArticleDOI
A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells
TL;DR: Investigation demonstrated that STA-21 inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity, and reduces the survival of breast carcinoma cells with constitutive Stat3 signaling but has minimal effect on the cells in which constitutive stat3 signaling is absent.
Journal ArticleDOI
Curcumin is a potent DNA hypomethylation agent.
Zhongfa Liu,Zhiliang Xie,William P. Jones,Ryan E. Pavlovicz,Shujun Liu,Jianhua Yu,Pui-Kai Li,Jiayuh Lin,Jame R. Fuchs,Guido Marcucci,Chenglong Li,Kenneth K. Chan +11 more
TL;DR: Curcumin inhibits the activity of M. SssI with an IC(50) of 30 nM, but no inhibitory activity of hexahydrocurcumin up to 100 microM, and can induce global DNA hypomethylation in a leukemia cell line.
Journal ArticleDOI
Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells
William M. Burke,Xiaohong Jin,Huey Jen Lin,Melinda Huang,Rebecca Liu,R. Kevin Reynolds,Jiayuh Lin +6 more
TL;DR: It is shown that inhibition of the Stat3 signaling pathway using the Janus Kinase-selective inhibitor, AG490, and a dominant negative Stat3 (Stat3β) significantly suppresses the growth of ovarian and breast cancer cell lines harboring constitutively active Stat3.
Journal Article
Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis.
TL;DR: Results suggest that Akt/AKT1 expressed in these clones can phosphorylate Bad and prevent it from binding to Bcl-XL and provide evidence that aberrant expression or activation of AKT in cancer cells may confer resistance to paclitaxel.
Journal ArticleDOI
Novel STAT3 Phosphorylation Inhibitors Exhibit Potent Growth-Suppressive Activity in Pancreatic and Breast Cancer Cells
Li Lin,Brian Hutzen,Mingxin Zuo,Sarah Ball,Stephanie Deangelis,Elizabeth Foust,Bulbul Pandit,Michael A. Ihnat,Satyendra S. Shenoy,Samuel K. Kulp,Pui-Kai Li,Chenglong Li,James R. Fuchs,Jiayuh Lin +13 more
TL;DR: FLLL31 and FLLL32 are effective inhibitors of STAT3 phosphorylation, DNA-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines.