Brian P. Kennedy

TL;DR: In this article, the mouse homolog of the gene encoding PTP-1B yielded healthy mice that, in the fed state, had blood glucose concentrations that were slightly lower and concentrations of circulating insulin that were one-half those of their PTP−1B+/+ littermates.

TL;DR: It is suggested that PTP1B negatively regulates leptin signaling, and provide one mechanism by which it may regulate obesity.

TL;DR: The development of a COX-2 inhibitor rofecoxib (MK 966, Vioxx) is described, essentially equipotent to indomethacin both in vitro and in vivo but without the ulcerogenic side effect due toCOX-1 inhibition.

TL;DR: Rofecoxib is a novel COX-2 inhibitor with a biochemical and pharmacological profile clearly distinct from that of current nonsteroidal anti-inflammatory drugs and represents a new therapeutic class of anti- inflammatory agents for the treatment of the symptoms of osteoarthritis and rheumatoid arthritis with improved gastrointestinal tolerability.

TL;DR: The oPOSSUM system as discussed by the authors combines a pre-computed database of conserved transcription factor binding sites in human and mouse promoters with statistical methods for identification of sites overrepresented in a set of coexpressed genes.