M
Michael J. Gresser
Researcher at Merck & Co.
Publications - 57
Citations - 6031
Michael J. Gresser is an academic researcher from Merck & Co.. The author has contributed to research in topics: Vanadate & Vanadium. The author has an hindex of 27, co-authored 57 publications receiving 5873 citations. Previous affiliations of Michael J. Gresser include Concordia University Wisconsin & Simon Fraser University.
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Journal ArticleDOI
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.
Mounib Elchebly,Paul Payette,Eva Michaliszyn,Wanda Cromlish,Susan Collins,Ailsa Lee Loy,Denis Normandin,Alan Cheng,Jean Himms-Hagen,Chi-Chung Chan,Chidambaram Ramachandran,Michael J. Gresser,Michel L. Tremblay,Brian P. Kennedy +13 more
TL;DR: In this article, the mouse homolog of the gene encoding PTP-1B yielded healthy mice that, in the fed state, had blood glucose concentrations that were slightly lower and concentrations of circulating insulin that were one-half those of their PTP−1B+/+ littermates.
Journal ArticleDOI
Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate
Gregory Huyer,Susana Liu,John F. Kelly,Jason Moffat,Paul Payette,Brian K. Kennedy,George Tsaprailis,Michael J. Gresser,Chidambaram Ramachandran +8 more
TL;DR: The results show that vanadate is a competitive inhibitor for the protein-tyrosine phosphatase PTP1B, with a Ki of 0.38 ± 0.02 μM, and reducing agents such as dithiothreitol that are used in PTP assays to keep the catalytic cysteine reduced and active were found to convert pervanadate rapidly toVanadate.
Journal Article
Etoricoxib (MK-0663): Preclinical Profile and Comparison with Other Agents That Selectively Inhibit Cyclooxygenase-2
Denis Riendeau,M.D. Percival,Christine Brideau,Stella Charleson,Daniel Dube,Diane Ethier,Jean-Pierre Falgueyret,Richard Friesen,R. Gordon,Gillian Greig,Jocelyne Guay,Joseph A. Mancini,Marc Ouellet,E. Wong,Lijing Xu,Susan Boyce,Denise M. Visco,Yves Girard,Petpiboon Prasit,Robert Zamboni,Ian W. Rodger,Michael J. Gresser,Anthony W. Ford-Hutchinson,Robert N. Young,Chi-Chung Chan +24 more
TL;DR: Etoricoxib represents a novel agent that selectively inhibits COX-2 with 106-fold selectivity in human whole blood assays in vitro and with the lowest potency of inhibition ofCOX-1 compared with other reported selective agents.
Journal ArticleDOI
The discovery of rofecoxib, [MK 966, VIOXX®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor
Petpiboon Prasit,Zhaoyin Wang,Christine Brideau,Chi-Chung Chan,Stella Charleson,Wanda Cromlish,Diane Ethier,Jillian F. Evans,Anthony W. Ford-Hutchinson,Jacques-Yves Gauthier,R. Gordon,Jocelyne Guay,Michael J. Gresser,Stacia Kargman,Brian P. Kennedy,Yves Leblanc,Serge Leger,Joseph A. Mancini,Gary P. O'Neill,Marc Ouellet,M.D. Percival,Helene Perrier,Denis Riendeau,Ian W. Rodger,Philip Tagari,Michael J. Therien,Philip J. Vickers,E. Wong,Lijing Xu,Robert N. Young,Robert Zamboni,Susan Boyce,Nadia M.J. Rupniak,Michael J. Forrest,Denise M. Visco,D Patrick +35 more
TL;DR: The development of a COX-2 inhibitor rofecoxib (MK 966, Vioxx) is described, essentially equipotent to indomethacin both in vitro and in vivo but without the ulcerogenic side effect due toCOX-1 inhibition.
Journal Article
Rofecoxib [Vioxx, MK-0966; 4-(4′-Methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: A Potent and Orally Active Cyclooxygenase-2 Inhibitor. Pharmacological and Biochemical Profiles
Chi-Chung Chan,Susan Boyce,Christine Brideau,Stella Charleson,Wanda Cromlish,Diane Ethier,Jillian F. Evans,Anthony W. Ford-Hutchinson,Michael J. Forrest,Jacques-Yves Gauthier,R. Gordon,Michael J. Gresser,Jocelyne Guay,Stacia Kargman,Brian P. Kennedy,Yves Leblanc,Serge Leger,Joseph A. Mancini,Gary P. O'Neill,Marc Ouellet,D Patrick,Percival,Helene Perrier,Petpiboon Prasit,Ian W. Rodger +24 more
TL;DR: Rofecoxib is a novel COX-2 inhibitor with a biochemical and pharmacological profile clearly distinct from that of current nonsteroidal anti-inflammatory drugs and represents a new therapeutic class of anti- inflammatory agents for the treatment of the symptoms of osteoarthritis and rheumatoid arthritis with improved gastrointestinal tolerability.