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Brian W Chow
Researcher at Harvard University
Publications - 8
Citations - 1091
Brian W Chow is an academic researcher from Harvard University. The author has contributed to research in topics: Inhibitory postsynaptic potential & Transcytosis. The author has an hindex of 6, co-authored 8 publications receiving 654 citations.
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Journal ArticleDOI
Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis.
Benjamin J. Andreone,Brian W Chow,Aleksandra Tata,Baptiste Lacoste,Ayal Ben-Zvi,Kevin Bullock,Amy Deik,David D. Ginty,Clary B. Clish,Chenghua Gu +9 more
TL;DR: Lipids transported by Mfsd2a establish a unique lipid environment that inhibits caveolae vesicle formation in CNS endothelial cells to suppress transcytosis and ensure BBB integrity.
Journal ArticleDOI
The molecular constituents of the blood-brain barrier.
Brian W Chow,Chenghua Gu +1 more
TL;DR: A review of recent findings describing the molecular determinants and core cellular pathways that confer BBB properties on CNS endothelial cells highlights the physiological significance of the blood-brain barrier in health and disease.
Journal ArticleDOI
Neuronal regulation of the blood–brain barrier and neurovascular coupling
TL;DR: The homeostatic CNS environment is maintained by the function of the blood–blood barrier and neurovascular coupling, which ensures that, following local neural activation, regional blood flow is increased to quickly supply more nutrients and remove metabolic waste.
Journal ArticleDOI
Caveolae in CNS arterioles mediate neurovascular coupling
Brian W Chow,Vicente Nuñez,Luke Kaplan,Adam J. Granger,Adam J. Granger,Karina Bistrong,Hannah L. Zucker,Payal Kumar,Bernardo L. Sabatini,Bernardo L. Sabatini,Chenghua Gu +10 more
TL;DR: These findings indicate that vasodilation is largely mediated by endothelial cells that actively relay signals from the central nervous system to SMCs via a caveolae-dependent pathway, an essential function for meeting acute brain energy demand.
Journal ArticleDOI
Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation
Brian W Chow,Chenghua Gu +1 more
TL;DR: It is found that immature vessel leakage occurs entirely through transcytosis, as specialized tight junctions are functional as early as vessel entry into the CNS.