B
Brice Felden
Researcher at University of Rennes
Publications - 98
Citations - 3450
Brice Felden is an academic researcher from University of Rennes. The author has contributed to research in topics: RNA & Ribosome. The author has an hindex of 34, co-authored 93 publications receiving 3078 citations. Previous affiliations of Brice Felden include University of Utah & French Institute of Health and Medical Research.
Papers
More filters
Journal ArticleDOI
Small RNA genes expressed from Staphylococcus aureus genomic and pathogenicity islands with specific expression among pathogenic strains
Christophe Pichon,Brice Felden +1 more
TL;DR: In vitro binding assays indicate that one sRNA encoded within a pathogenicity island is a trans-encoded antisense RNA regulating the expression of target genes at the posttranscriptional level, suggesting that they are involved in the regulation of staphylococcal virulence.
Journal ArticleDOI
Experimental discovery of small RNAs in Staphylococcus aureus reveals a riboregulator of central metabolism
Chantal Bohn,Candice Rigoulay,Svetlana Chabelskaya,Cynthia M. Sharma,Antonin Marchais,Patricia Skorski,Elise Borezée-Durant,Romain Barbet,Eric Jacquet,Annick Jacq,Daniel Gautheret,Brice Felden,Jörg Vogel,Philippe Bouloc +13 more
TL;DR: A combination of biocomputational and transcriptional analyses revealed a remarkably coordinated RsaE-dependent downregulation of numerous metabolic enzymes involved in the citrate cycle and the folate-dependent one-carbon metabolism.
Journal ArticleDOI
The Staphylococcus aureus RNome and its commitment to virulence.
TL;DR: This work focuses on the recently inventoried S. aureus regulatory RNAs, with emphasis on those with identified functions, two of which are directly involved in pathogenicity.
Journal ArticleDOI
A Staphylococcus aureus small RNA is required for bacterial virulence and regulates the expression of an immune-evasion molecule.
TL;DR: It is demonstrated that SprD negatively regulates the expression of the Sbi immune-evasion molecule, impairing both the adaptive and innate host immune responses, and prevents translation initiation of sbi mRNA by an antisense mechanism.
Journal ArticleDOI
Ribosome Rescue by tmRNA Requires Truncated mRNAs
TL;DR: It is concluded that tmRNA action in vivo must always be preceded by mRNA truncation, and it is suggested that cleavage of ribosome bound mRNAs is a common element in different bacterial stress responses.