Bridgeen Callan

TL;DR: The breath of evidence from in-vitro and in- vivo SDT-based studies is explored, providing the reader with an insight into the therapeutic potential offered by SDT in the treatment of cancer.

TL;DR: A new class of iodinated cyanine dyes have been prepared for use in NIR excited photodynamic therapy (PDT) and demonstrated improved efficacy in two pancreatic cell lines as well as excellent tumour control in a murine model of the disease.

TL;DR: The use of MBs to facilitate delivery of O2 as well as the sensitisers/antimetabolite, combined with the possibility to activate the sensitiser using externally applied ultrasound, provides a more targeted approach with improved efficacy and reduced side effects when compared with conventional systemic administration of antimetabolite drugs alone.

TL;DR: The results presented in this manuscript suggest that chemo‐sonodynamic therapy using the O2 MB‐Gem and O2MB‐RB conjugates, is potentially an effective targeted and safe treatment modality for pancreatic cancer.

TL;DR: The results suggest that the polymer coated CaO2 NP formulation offers significant potential as an in situ method for oxygen generation to enhance the efficacy of treatments that depend on the presence of oxygen to elicit a cytotoxic effect.