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Colin Fowley
Researcher at Ulster University
Publications - 22
Citations - 1409
Colin Fowley is an academic researcher from Ulster University. The author has contributed to research in topics: Sonodynamic therapy & Aqueous solution. The author has an hindex of 17, co-authored 21 publications receiving 1100 citations.
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Journal ArticleDOI
Treating cancer with sonodynamic therapy: A review
David Costley,Conor Mc Ewan,Colin Fowley,Anthony P. McHale,Jordan Atchison,Nikolitsa Nomikou,John F. Callan +6 more
TL;DR: This article critically review the current literature on SDT and discusses strategies that have been developed in combination with SDT to enhance the therapeutic outcome.
Journal ArticleDOI
Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours.
Conor McEwan,Joshua Owen,Eleanor Stride,Colin Fowley,Heather Nesbitt,david cochrane,Constantin C. Coussios,Mark A. Borden,Nikolitsa Nomikou,Anthony P. McHale,John F. Callan +10 more
TL;DR: This manuscript investigates the use of oxygen-loaded, lipid-stabilised microbubbles (MBs), decorated with a Rose Bengal sensitiser, for SDT-based treatment of a pancreatic cancer model (BxPc-3) in vitro and in vivo and reveals a significant improvement in therapeutic efficacy.
Book ChapterDOI
Sonodynamic Therapy: Concept, Mechanism and Application to Cancer Treatment.
TL;DR: The breath of evidence from in-vitro and in- vivo SDT-based studies is explored, providing the reader with an insight into the therapeutic potential offered by SDT in the treatment of cancer.
Journal ArticleDOI
Iodinated cyanine dyes: a new class of sensitisers for use in NIR activated photodynamic therapy (PDT)
Jordan Atchison,Sukanta Kamila,Heather Nesbitt,Keiran Logan,Dean Nicholas,Colin Fowley,James Davis,Bridgeen Callan,Anthony P. McHale,John F. Callan +9 more
TL;DR: A new class of iodinated cyanine dyes have been prepared for use in NIR excited photodynamic therapy (PDT) and demonstrated improved efficacy in two pancreatic cell lines as well as excellent tumour control in a murine model of the disease.
Journal ArticleDOI
Extending the tissue penetration capability of conventional photosensitisers: a carbon quantum dot–protoporphyrin IX conjugate for use in two-photon excited photodynamic therapy
TL;DR: A carbon quantum dot (CQD)-protoporphyrin (IX) sensitisier conjugate was designed to exploit the large two-photon absorption cross section of CQDs and enable the indirect excitation of the sensitiser with 800 nm irradiation via FRET.