For pt.I see ibid., vol.20, no.2, p.404-18, 1990. The basic aspects of the FLC (fuzzy logic controller) decision-making logic are examined. Several issues, including the definitions of a fuzzy implication, compositional operators, the interpretations of the sentence connectives 'and' and 'also', and fuzzy inference mechanisms, are investigated. Defuzzification strategies, are discussed. Some of the representative applications of the FLC, from laboratory level to industrial process control, are briefly reported. Some unsolved problems are described, and further challenges in this field are discussed. >

Fuzzy logic in control systems: fuzzy logic controller. II

During the past several years, fuzzy control has emerged as one of the most active and fruitful areas for research in the applications of fuzzy set theory. Fuzzy control is based on fuzzy logic. The fuzzy logic controller (FLC) based on fuzzy logic provides a means of converting a linguistic control strategy based on expert knowledge into an automatic control strategy. A survey of the FLC is presented; a general methodology for constructing an FLC and assessing its performance is described; and problems that need further research are pointed out

Fuzzy logic in control systems : fuzzy logic controller. Part II

Muscle fatigue is an exercise-induced reduction in maximal voluntary muscle force. It may arise not only because of peripheral changes at the level of the muscle, but also because the central nervous system fails to drive the motoneurons adequately. Evidence for “central” fatigue and the neural mechanisms underlying it are reviewed, together with its terminology and the methods used to reveal it. Much data suggest that voluntary activation of human motoneurons and muscle fibers is suboptimal and thus maximal voluntary force is commonly less than true maximal force. Hence, maximal voluntary strength can often be below true maximal muscle force. The technique of twitch interpolation has helped to reveal the changes in drive to motoneurons during fatigue. Voluntary activation usually diminishes during maximal voluntary isometric tasks, that is central fatigue develops, and motor unit firing rates decline. Transcranial magnetic stimulation over the motor cortex during fatiguing exercise has revealed focal cha...

Spinal and Supraspinal Factors in Human Muscle Fatigue

中枢神経系疾患の治療は正常細胞（ニューロン）の機能維持を目的とするが，脳血管障害のように機能障害の原因が細胞の死滅に基づくことは多い．一方，脳腫瘍の治療においては薬物療法や放射線療法といった腫瘍細胞の死滅を目標とするものが大きな位置を占める．いずれの場合にも，細胞死の機序を理解することは各種病態や治療法の理解のうえで重要である．現在のところ最も研究の進んでいる細胞死の型はアポトーシスである．そのなかで重要な位置を占めるミトコンドリアにおける反応および抗アポトーシス因子について概要を紹介する．

Neuroscience 細胞死：最近の知見

Fuzzy controllers are a class of knowledge based controllers using artificial intelligence techniques with origins in fuzzy logic. They can be found either as stand-alone control elements or as int ...

An Introduction to Fuzzy Control

Preface 1. Introduction 2. The basis of electrical activity in the neuron 3. The Hodgkin Huxley model of the action potential 4. Compartmental models 5. Models of active ion channels 6. Intracellular mechanisms 7. The synapse 8. Simplified models of neurons 9. Networks 10. The development of the nervous system Appendix A. Resources Appendix B. Mathematical methods References.

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Principles of Computational Modelling in Neuroscience

Nitric oxide is a volume transmitter regulating postsynaptic excitability at a glutamatergic synapse.

It has been proposed that the hippocampal theta rhythm (4-7 Hz) can contribute to memory formation by separating encoding (storage) and retrieval of memories into different functional half-cycles (Hasselmo et al. (2002) Neural Comput 14:793-817). We investigate, via computer simulations, the biophysical mechanisms by which storage and recall of spatio-temporal input patterns are achieved by the CA1 microcircuitry. A model of the CA1 microcircuit is presented that uses biophysical representations of the major cell types, including pyramidal (P) cells and four types of inhibitory interneurons: basket (B) cells, axo-axonic (AA) cells, bistratified (BS) cells and oriens lacunosum-moleculare (OLM) cells. Inputs to the network come from the entorhinal cortex (EC), the CA3 Schaffer collaterals and medial septum. The EC input provides the sensory information, whereas all other inputs provide context and timing information. Septal input provides timing information for phasing storage and recall. Storage is accomplished via a local STDP mediated hetero-association of the EC input pattern and the incoming CA3 input pattern on the CA1 pyramidal cell target synapses. The model simulates the timing of firing of different hippocampal cell types relative to the theta rhythm in anesthetized animals and proposes experimentally confirmed functional roles for the different classes of inhibitory interneurons in the storage and recall cycles (Klausberger et al., (2003, 2004) Nature 421:844-848, Nat Neurosci 7:41-47). Measures of recall performance of new and previously stored input patterns in the presence or absence of various inhibitory interneurons are employed to quantitatively test the performance of our model. Finally, the mean recall quality of the CA1 microcircuit is tested as the number of stored patterns is increased.

/pdf/encoding-and-retrieval-in-a-model-of-the-hippocampal-ca1-w3ijkhkodz.pdf

Encoding and retrieval in a model of the hippocampal CA1 microcircuit.

Short-term facilitation and depression have a profound influence on transmission at many glutamatergic synapses, particularly during trains of stimuli. A major component of these processes is postsynaptic receptor desensitization. Both presynaptic and postsynaptic mechanisms can contribute to synaptic efficacy, but it is often difficult to define their respective contributions. Blockers of desensitization such as cyclothiazide (CTZ) can be used, but many of these drugs have nonspecific effects on transmitter release, complicating attempts to define synaptic effectiveness under physiological conditions. We describe and validate a new method to minimize desensitization during trains of synaptic stimuli that is based on the low-affinity competitive glutamate receptor antagonists γ-d-glutamylglycine or kynurenic acid. A computational model of AMPA receptor kinetics shows that the mechanism can be accounted for by simple competitive antagonism of AMPA receptors, where the rapid off-rate of the antagonist permits re-equilibration between blocked and unblocked pools during the interstimulus interval. Our results at the calyx of Held show that desensitization makes little contribution to synaptic depression at frequencies below 10 Hz, but at higher frequencies it makes an important contribution, with accumulating desensitization masking short-term facilitation and causing an underestimation of quantal content. This novel method of protection from desensitization is compatible with physiological studies but cannot be used in conjunction with CTZ. Although presynaptic vesicle depletion makes the dominant contribution to short-term depression, our results show that AMPA receptor desensitization contributes to the depression at auditory synapses after hearing onset and in a frequency-dependent manner.

https://www.jneurosci.org/content/jneuro/23/12/4868.full.pdf

Distinguishing between Presynaptic and Postsynaptic Mechanisms of Short-Term Depression during Action Potential Trains

1. During presynaptic inhibition, an increased conductance in the membrane of the presynaptic bouton is presumed to reduce the action potential, thereby reducing transmitter release. The object of ...

Bruce P. Graham

Papers

Principles of Computational Modelling in Neuroscience

Nitric oxide is a volume transmitter regulating postsynaptic excitability at a glutamatergic synapse.

Encoding and retrieval in a model of the hippocampal CA1 microcircuit.

Distinguishing between Presynaptic and Postsynaptic Mechanisms of Short-Term Depression during Action Potential Trains

A simulation of action potentials in synaptic boutons during presynaptic inhibition