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Bruna Pippi
Researcher at Universidade Federal do Rio Grande do Sul
Publications - 37
Citations - 663
Bruna Pippi is an academic researcher from Universidade Federal do Rio Grande do Sul. The author has contributed to research in topics: Clioquinol & Candida glabrata. The author has an hindex of 11, co-authored 34 publications receiving 443 citations. Previous affiliations of Bruna Pippi include Universidade Federal de Santa Maria.
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Antifungals discovery: an insight into new strategies to combat antifungal resistance
TL;DR: The most recent discoveries in drug resistance mechanism and their avoidance were explored in a review, focusing on different antifungal targets, as well as new agents or strategies, such as combination therapy, that could improve antIFungal therapy.
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Antifungal activity and mechanism of action of monoterpenes against dermatophytes and yeasts
Diogo Miron,Fernanda Battisti,Fernanda da Silva,Aline Jacobi Dalla Lana,Bruna Pippi,Bruna Bento Casanova,Simone Cristina Baggio Gnoatto,Alexandre Meneghello Fuentefria,Paulo Mayorga,Elfrides Eva Scherman Schapoval +9 more
TL;DR: The monoterpenes showed an affinity for ergosterol relating their mechanism of action to cell membrane destabilization in the fungal cell wall and in the cell membrane (Ergosterol Affinity Assay).
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In vitro evaluation of the acquisition of resistance, antifungal activity and synergism of Brazilian red propolis with antifungal drugs on Candida spp.
Bruna Pippi,Aline Jacobi Dalla Lana,Renata Cougo Moraes,Camila Martins Güez,Michel Mansur Machado,L.F.S. de Oliveira,G. Lino von Poser,Alexandre Meneghello Fuentefria +7 more
TL;DR: To evaluate the ability of Candida parapsilosis and Candida glabrata to develop phenotypic resistance to a benzophenone enriched fraction obtained from Brazilian red propolis as compared to fluconazole and investigate possible synergy between BZP‐BRP and FLC and anidulafungin.
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New insights into the mechanism of antifungal action of 8-hydroxyquinolines.
Bruna Pippi,William Lopes,Paula Reginatto,Fernanda Émili Klein Silva,Angélica Rocha Joaquim,Ricardo José Alves,Gustavo Pozza Silveira,Marilene Henning Vainstein,Saulo Fernandes de Andrade,Alexandre Meneghello Fuentefria +9 more
TL;DR: The results reinforce the potential of 8-hydroxyquinolines for the development of new drugs and the broad antifungal spectrum already demonstrated previously.
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Evaluation of 8-Hydroxyquinoline Derivatives as Hits for Antifungal Drug Design
Bruna Pippi,Paula Reginatto,Gabriella da Rosa Monte Machado,Vanessa Zafaneli Bergamo,Daiane Flores Dalla Lana,Mário Lettieri Teixeira,Lucas L. Franco,Ricardo José Alves,Saulo Fernandes de Andrade,Alexandre Meneghello Fuentefria +9 more
TL;DR: Clioquinol and 8‐hydroxy‐5‐quinolinesulfonic acid demonstrated the potential for antifungal drug design and all compounds showed fungistatic effect for Candida, 8‐Hydroxy‐7‐iodo‐5-quinolineulfonic acids showed a fungicidal effect for M. canis and T. mentagrophytes, and clioquinols presented a fungicide effect depending on the time and concentration.