Showing papers by "Bruno de Sousa published in 2016"
TL;DR: In this paper, the authors evaluated the effects of time 1 predictors (e.g., depressive symptoms, life events, subjective well-being, and emotion regulation strategies) on depressive symptoms assessed at time 2 (1 year later).
Abstract: Etiological research regarding adolescent depression is relatively recent and longitudinal studies are needed to explicate the mechanisms by which risk and protective factors impact the development of depression. This investigation evaluated the effects of time 1 predictors (e.g., depressive symptoms, life events, subjective well-being, and emotion regulation strategies) on depressive symptoms assessed at time 2 (1 year later). The sample comprised 182 Portuguese adolescents, aged 12–16. Time 1 depressive symptoms and psychological well-being were significant predictors of time 2 depressive symptoms. Time 1 rumination predicted time 2 depressive symptoms, but time 2 brooding mediated this effect. Time 1 life events did not predict time 2 depressive symptomatology. This study identified several factors that seem to play an important role in the development of depressive symptomatology. Previous depressive symptomatology and well-being had a significant effect in this process and the relationship between rumination in time 1 and depressive symptoms at time 2 (1 year later) was fully mediated by brooding at time 2. Given these results, implications for prevention and treatment of depression include addressing risk factors like early depressive symptoms, rumination and brooding, and increasing the protective effect of psychological well-being.
14 citations
TL;DR: The authors compared three groups consisting of individuals with no gambling problem, those with some problem, and pathological gamblers, according to the following four levels of analysis: social context (i.e., accessibility and social acceptance), family context, family functioning, and family quality of life), marital issues, and individual issues.
Abstract: This study compares 3 groups consisting of individuals with no gambling problem, those with some problem, and pathological gamblers, according to the following 4 levels of analysis: social context (i.e., accessibility and social acceptance), family context (i.e., family of origin issues, family functioning, and family quality of life), marital issues (i.e., marital satisfaction and adjustment), and individual issues (i.e., congruence, differentiation of self, and psychopathological symptoms). The study protocol of 8 standardized scales, a sociodemographic questionnaire, and 6 independent questions was administered to 331 adults. The main results indicate that although the 2 groups of nonpathological gamblers exhibited differing levels of gambling severity, they did not differ statistically, suggesting that gambling-related problems were only evident when a pathological level was attained. The pathological gamblers exhibited a greater number of family, marital, and individual difficulties compared to the o...
5 citations
TL;DR: All three synthetic ozonides showed high efficacy in clearing parasitaemia in mice, caused by multi-drug resistant Plasmodium chabaudi strains, by subcutaneous administration, demonstratinghigh efficacy in vivo against ART and artesunate resistant parasites.
Abstract: Ever increasing multi-drug resistance by Plasmodium falciparum is creating new challenges in malaria chemotherapy In the absence of licensed vaccines, treatment and prevention of malaria is heavily dependent on drugs Potency, range of activity, safety, low cost and ease of administration are crucial issues in the design and formulation of antimalarials We have tested three synthetic ozonides NAC89, LC50 and LCD67 in vitro and in vivo against multidrug resistant Plasmodium In vitro, LC50 was at least 10 times more efficient inhibiting P falciparum multidrug resistant Dd2 strain than chloroquine and mefloquine and as efficient as artemisinin (ART), artesunate and dihydroartemisinin All three ozonides showed high efficacy in clearing parasitaemia in mice, caused by multi-drug resistant Plasmodium chabaudi strains, by subcutaneous administration, demonstrating high efficacy in vivo against ART and artesunate resistant parasites
2 citations
01 Jan 2016
TL;DR: The main findings suggest the existence of significant regional differences in Portugal, with the fact of being female and/or alcohol dependent contributing to an increased delay-time in diagnosis, while being dependent on intravenous drugs and/ or being diagnosed with HIV are factors that increase the chance of an earlier diagnosis of pulmonary TB.
Abstract: Understanding what characterizes patients who suffer great delays in diagnosis of pulmonary tuberculosis is of great importance when establishing screening strategies to better control TB Greater delays in diagnosis imply a higher chance for susceptible individuals to become infected by a bacilliferous patient A structured additive regression model is attempted in this study in order to potentially contribute to a better characterization of bacilliferous prevalence in Portugal The main findings suggest the existence of significant regional differences in Portugal, with the fact of being female and/or alcohol dependent contributing to an increased delay-time in diagnosis, while being dependent on intravenous drugs and/or being diagnosed with HIV are factors that increase the chance of an earlier diagnosis of pulmonary TB A decrease in 2010 to 77 % on treatment success in Portugal underlines the importance of conducting more research aimed at better TB control strategies
1 citations