B
Buyong Ma
Researcher at Leidos
Publications - 223
Citations - 18233
Buyong Ma is an academic researcher from Leidos. The author has contributed to research in topics: Protein structure & Protein folding. The author has an hindex of 61, co-authored 217 publications receiving 16506 citations. Previous affiliations of Buyong Ma include National Cancer Research Institute & Shanghai Jiao Tong University.
Papers
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Principles of docking: An overview of search algorithms and a guide to scoring functions
TL;DR: The docking field has come of age, and the time is ripe to present the principles of docking, reviewing the current state of the field from both the computational and the biological points of view.
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Is allostery an intrinsic property of all dynamic proteins
TL;DR: It is argued that all (nonfibrous) proteins are potentially allosteric, and experimental observations validating this view of protein allostery are reviewed.
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Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease
Yiling Xiao,Buyong Ma,Dan McElheny,Sudhakar Parthasarathy,Fei Long,Minako Hoshi,Ruth Nussinov,Yoshitaka Ishii +7 more
TL;DR: The atomic model of an Aβ(1–42) amyloid fibril, from solid-state NMR (ssNMR) data, is presented, providing insight into the A β(1-42)-selective self-replicating amyloids-propagation machinery in early-stage Alzheimer's disease.
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Folding funnels, binding funnels, and protein function
TL;DR: The shape of the funnels is described in light of protein synthesis and folding; flexibility, conformational diversity, and binding mechanisms; and the associated binding funnels, illustrating the multiple routes and the range of complexed conformers.
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Protein–protein interactions: Structurally conserved residues distinguish between binding sites and exposed protein surfaces
TL;DR: It is shown that hot spots occur predominantly at the interfaces of macromolecular complexes, distinguishing binding sites from the remainder of the surface, Consequently, hot spots can be used to define binding epitopes and a correspondence between energy hot spots and structurally conserved residues is shown.