K
Kannan Gunasekaran
Researcher at Amgen
Publications - 47
Citations - 3747
Kannan Gunasekaran is an academic researcher from Amgen. The author has contributed to research in topics: Protein structure & Protein folding. The author has an hindex of 25, co-authored 47 publications receiving 3418 citations. Previous affiliations of Kannan Gunasekaran include Science Applications International Corporation & Indian Institute of Science.
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Journal ArticleDOI
Is allostery an intrinsic property of all dynamic proteins
TL;DR: It is argued that all (nonfibrous) proteins are potentially allosteric, and experimental observations validating this view of protein allostery are reviewed.
Journal ArticleDOI
Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects: APPLICATIONS TO BISPECIFIC MOLECULES AND MONOVALENT IgG
Kannan Gunasekaran,Martin Pentony,Min Shen,Logan Garrett,Carla Forte,Anne Woodward,Soo Bin Ng,Teresa L. Born,Marc W. Retter,Kathy Manchulenko,Heather Sweet,Ian Foltz,Michael Wittekind,Wei Yan +13 more
TL;DR: This work modified the CH3 domain interface of the antibody Fc region with selected mutations so that the engineered Fc proteins preferentially form heterodimers, demonstrating the feasibility of robust production of novel Fc-based heterodimeric molecules.
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Extended disordered proteins: targeting function with less scaffold
TL;DR: Disordered proteins provide a simple yet elegant solution to having large intermolecular interfaces, but with smaller protein, genome and cell sizes, to conserve energy.
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A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair
Monica Florio,Kannan Gunasekaran,Marina Stolina,Xiaodong Li,Ling Liu,Barbara Tipton,Hossein Salimi-Moosavi,Franklin J. Asuncion,Chaoyang Li,Banghua Sun,Hong Lin Tan,Li Zhang,Chun-Ya Han,Ryan Case,Amy N. Duguay,Mario Grisanti,Jennitte Stevens,James Pretorius,Efrain Pacheco,Heidi Jones,Qing Chen,Brian Soriano,Jie Wen,Brenda Heron,Frederick W. Jacobsen,Emil Brisan,William G. Richards,Hua Zhu Ke,Michael S. Ominsky +28 more
TL;DR: It is demonstrated that dual inhibition of sclerostin and DKK-1 leads to synergistic bone formation in rodents and non-human primates, and by targeting distinct facets of fracture healing, the bispecific antibody shows superior bone repair activity compared with monotherapies.
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Beta-hairpins in proteins revisited: lessons for de novo design.
TL;DR: The results presented in this study provide inputs for the de novo design of consensus loop segments in synthetic hairpins by estimation of the specific amino acid preferences for loop positions in two, three and four residue loops.