C
C Berne
Researcher at Uppsala University Hospital
Publications - 8
Citations - 1286
C Berne is an academic researcher from Uppsala University Hospital. The author has contributed to research in topics: Islet & Transplantation. The author has an hindex of 7, co-authored 8 publications receiving 1229 citations.
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Journal ArticleDOI
Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation
Lisa Moberg,Helena Johansson,Agneta Lukinius,C Berne,Aksel Foss,Ragnar Källén,Ø Østraat,Kaija Salmela,Annika Tibell,Gunnar Tufveson,Graciela Elgue,K Nilsson Ekdahl,Olle Korsgren,Bo Nilsson +13 more
TL;DR: Blockade of TF represents a new therapeutic approach that might increase the success of islet transplantation in patients with type 1 diabetes, in terms of both the risk of intraportal thrombosis and the need for islets from more than one donor.
Journal ArticleDOI
Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation.
Helena Johansson,Agneta Lukinius,Lisa Moberg,Torbjörn Lundgren,C Berne,Aksel Foss,Marie Felldin,Ragnar Källén,Kaija Salmela,Annika Tibell,Gunnar Tufveson,Kristina Nilsson Ekdahl,Graciela Elgue,Olle Korsgren,Bo Nilsson +14 more
TL;DR: It is shown that islets intended for islet transplantation produce tissue factor in both the transmembrane and the alternatively spliced form and that the membrane-bound form is released as microparticles often associated with both insulin and glucagon granules.
Journal ArticleDOI
Direct medical costs for patients with type 2 diabetes in Sweden
Freddie Henriksson,Carl-David Agardh,C Berne,Jan Bolinder,Fredrik Lönnqvist,P Stenstrom,Claes-Göran Östenson,Bengt Jönsson +7 more
TL;DR: Direct medical costs for patients with type 2 diabetes in Sweden are calculated using data from the Karolinska Institute, University Hospital MAS, Malmö and SmithKline Beecham Pharmaceuticals AB.
Journal ArticleDOI
Current status of clinical islet transplantation.
Olle Korsgren,Bo Nilsson,C Berne,Marie Felldin,Aksel Foss,Ragnar Källén,Torgny Lundgren,Kaija Salmela,Annika Tibell,Gunnar Tufveson +9 more
TL;DR: In order to establish islet transplantation as a widely accepted treatment modality, and make tolerance induction regimes applicable, it is essential that the donor:recipient ratio is brought down to 1:1.
Journal ArticleDOI
Reduced Leptin Concentrations in Subjects With Type 2 Diabetes Mellitus in Sudan
TL;DR: It is shown in a large cohort of Sudanese subjects with type 2 diabetes that circulating leptin levels are lower in diabetic subjects than in controls of similar age and BMI, which may be a consequence of differences in fat distribution.