K
Kaija Salmela
Researcher at University of Helsinki
Publications - 116
Citations - 5157
Kaija Salmela is an academic researcher from University of Helsinki. The author has contributed to research in topics: Transplantation & Kidney transplantation. The author has an hindex of 37, co-authored 116 publications receiving 4913 citations. Previous affiliations of Kaija Salmela include Finnish Red Cross & Helsinki University Central Hospital.
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Journal ArticleDOI
Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation
Lisa Moberg,Helena Johansson,Agneta Lukinius,C Berne,Aksel Foss,Ragnar Källén,Ø Østraat,Kaija Salmela,Annika Tibell,Gunnar Tufveson,Graciela Elgue,K Nilsson Ekdahl,Olle Korsgren,Bo Nilsson +13 more
TL;DR: Blockade of TF represents a new therapeutic approach that might increase the success of islet transplantation in patients with type 1 diabetes, in terms of both the risk of intraportal thrombosis and the need for islets from more than one donor.
Journal ArticleDOI
Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation.
Helena Johansson,Agneta Lukinius,Lisa Moberg,Torbjörn Lundgren,C Berne,Aksel Foss,Marie Felldin,Ragnar Källén,Kaija Salmela,Annika Tibell,Gunnar Tufveson,Kristina Nilsson Ekdahl,Graciela Elgue,Olle Korsgren,Bo Nilsson +14 more
TL;DR: It is shown that islets intended for islet transplantation produce tissue factor in both the transmembrane and the alternatively spliced form and that the membrane-bound form is released as microparticles often associated with both insulin and glucagon granules.
Journal ArticleDOI
Refinement of the automated method for human islet isolation and presentation of a closed system for in vitro islet culture.
Masafumi Goto,Torsten Eich,Marie Felldin,Aksel Foss,Ragnar Källén,Kaija Salmela,Annika Tibell,Gunnar Tufveson,Keisei Fujimori,Margareta Engkvist,Olle Korsgren +10 more
TL;DR: A standardized technique of islet isolation is presented applying novel means to improve enzymatic digestion and to meet cGMP standards to enhance enzyme digestion and minimize mechanical forces during the digestion process.
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Islet Surface Heparinization Prevents the Instant Blood-Mediated Inflammatory Reaction in Islet Transplantation
Sanja Cabric,Javier Sanchez,Torbjörn Lundgren,Aksel Foss,Marie Felldin,Ragnar Källén,Kaija Salmela,Annika Tibell,Gunnar Tufveson,Rolf Larsson,Olle Korsgren,Bo Nilsson +11 more
TL;DR: This novel pretreatment procedure prevents intraportal thrombosis and efficiently inhibits the IBMIR without increasing the bleeding risk and, unlike other pretreatment procedures, without inducing acute or chronic toxicity in the islets.
Journal ArticleDOI
A randomized multicenter trial of the anti-ICAM-1 monoclonal antibody (enlimomab) for the prevention of acute rejection and delayed onset of graft function in cadaveric renal transplantation: a report of the European Anti-ICAM-1 Renal Transplant Study Group.
Kaija Salmela,L. Wramner,Henrik Ekberg,Ingeborg A. Hauser,Øystein Bentdal,Lars-eric Lins,Helena Isoniemi,Lars Bäckman,Persson Nh,Hans-Hellmut Neumayer,Päl Foyn Jørgensen,Claus Spieker,Bruce M. Hendry,Anthony Nicholls,Günter Kirste,Georg Hasche +15 more
TL;DR: Short term enlimomab induction therapy after renal transplantation did not reduce the rate of acute rejection or DGF and there was no statistically significant difference between the incidences between the two groups.