C. De Vigan

TL;DR: To assess at a population‐based level the frequency with which severe structural congenital malformations are detected prenatally in Europe and the gestational age at detection, and to describe regional variation in these indicators.

TL;DR: In this article, the authors examined trends in the live birth prevalence of Down syndrome in Europe in the light of trends in maternal age and in prenatal diagnosis, finding that the proportion of births to mothers of 35 years of age and over has risen quite dramatically from 8 to 14% for the European Union as a whole, with steeper rises in some regions.

TL;DR: Prenatal detection of Turner syndrome by ultrasound examination was high in this unselected population and prenatal counseling for 45,X mosaicism should take into account the expectation of a milder phenotype.

TL;DR: It is shown that ultrasound screening is an important tool in the prenatal detection of chromosomal abnormalities in Europe, leading to a significant reduction in the prevalence of livebirth children with chromosomal anomalies.

TL;DR: The Paris Registry of Congenital Malformations, which includes all births and pregnancy terminations with structural birth defects or chromosomal anomalies, provides population-based data on the prevalence of malforms and their associations with other anomalies.