H
H. E. K. De Walle
Researcher at University of Groningen
Publications - 34
Citations - 1384
H. E. K. De Walle is an academic researcher from University of Groningen. The author has contributed to research in topics: Pregnancy & Population. The author has an hindex of 16, co-authored 34 publications receiving 1281 citations. Previous affiliations of H. E. K. De Walle include University Medical Center Groningen.
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Journal ArticleDOI
Geographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas world wide
Bridget Wilcken,Fiona Bamforth,Zhu Li,H. Zhu,Annukka Ritvanen,M. Redlund,Claude Stoll,Yves Alembik,Beatrice Dott,Andrew E. Czeizel,Z. Gelman-Kohan,Gioacchino Scarano,S Bianca,G. Ettore,Romano Tenconi,S. Bellato,Iris Scala,Osvaldo M. Mutchinick,M. Lopez,H. E. K. De Walle,Robert M. W. Hofstra,L. Joutchenko,L. Kavteladze,Eva Bermejo,María Luisa Martínez-Frías,Margaret Gallagher,J D Erickson,Stein Emil Vollset,Pierpaolo Mastroiacovo,Generoso Andria,Lorenzo D. Botto +30 more
TL;DR: The aim was to supplement the available data by collecting a large and diverse sample of newborns from different geographical areas and ethnic groups, and to examine international variations in the distribution of the 677C>T allele.
Journal ArticleDOI
Tobacco and alcohol use during pregnancy and risk of oral clefts
C. Lorente,Sylvaine Cordier,J. Goujard,Ségolène Aymé,Fabrizio Bianchi,E. Calzolari,H. E. K. De Walle,Robin P. Knill-Jones +7 more
TL;DR: This study provides further evidence of the possible role of prevalent environmental exposures such as tobacco and alcohol in the etiology of oral clefts.
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Maternal occupational risk factors for oral clefts
C. Lorente,Sylvaine Cordier,Alain Bergeret,H. E. K. De Walle,J. Goujard,Ségolène Aymé,Robin P. Knill-Jones,Elisa Calzolari,Fabrizio Bianchi +8 more
TL;DR: With orofacial clefts: aliphatic aldehydes (OR 2.1, 95% CI 0.8-5.9) and glycol ethers (OR 1.7,95%CI 0.9-3.3) for cleft lip with or without cleft palate and lead compounds.
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Accuracy of family history of cancer : clinical genetic implications
Rolf H. Sijmons,Akkelies E. Boonstra,J. Reefhuis,Jannet M. Hordijk-Hos,H. E. K. De Walle,Jan C. Oosterwijk,Martina C. Cornel +6 more
TL;DR: In six out of 120 families verification data changed clinical genetic management, in five of these the genetic risk was reduced, and verification of reports on breast cancer can be limited without seriously compromising medical decision making.
Journal ArticleDOI
Trends and geographic inequalities in the prevalence of Down syndrome in Europe, 1980-1999
Helen Dolk,Maria Loane,Ester Garne,H. E. K. De Walle,Annette Queisser-Luft,C. De Vigan,Marie-Claude Addor,Blanca Gener,Martin Haeusler,H. Jordan,David Tucker,Claude Stoll,Maria Feijoo,D. Lillis,Fabrizio Bianchi +14 more
TL;DR: In this article, the authors examined trends in the live birth prevalence of Down syndrome in Europe in the light of trends in maternal age and in prenatal diagnosis, finding that the proportion of births to mothers of 35 years of age and over has risen quite dramatically from 8 to 14% for the European Union as a whole, with steeper rises in some regions.