C
C. Dubay
Researcher at French Institute of Health and Medical Research
Publications - 5
Citations - 986
C. Dubay is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Spontaneously hypertensive rat & Blood pressure. The author has an hindex of 4, co-authored 5 publications receiving 980 citations.
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Journal ArticleDOI
Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats.
P. Hilbert,Klaus Lindpaintner,Klaus Lindpaintner,Jacques S. Beckmann,Tadao Serikawa,Florent Soubrier,C. Dubay,P. Cartwright,B. de Gouyon,C Julier,S. Takahasi,M. Vincent,Detlev Ganten,Michel Georges,G.M. Lathrop +14 more
TL;DR: Comparison of the human and rat genetic maps indicates that BP/SP-1 could reside on human chromosome 17q in a region that also contains the angiotensin l-converting enzyme gene (ACE)8, and is therefore a candidate gene in primary hypertension.
Journal ArticleDOI
A radiation hybrid map of 506 STS markers spanning human chromosome 11.
M. R. James,M. R. James,Charles W. Richard,Jean-Jacques Schott,C. Yousry,K. Clark,John I. Bell,Joseph D. Terwilliger,J. Kazan,C. Dubay,Alain Vignal,M. Agrapart,Takashi Imai,Yusuke Nakamura,Mihael H. Polymeropoulos,Jean Weissenbach,David R. Cox,G.M. Lathrop +17 more
TL;DR: This work presents a high resolution radiation hybrid map of human chromosome 11 using 506 sequence tagged sites (STSs) scored on a panel of 86 radiation hybrids, and finds that more than half of the STSs are polymorphic microsatellite loci.
Journal ArticleDOI
Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats.
C. Dubay,Madeleine Vincent,Nilesh J. Samani,P. Hilbert,M.A. Kaiser,Beressi Jp,Yuri Kotelevtsev,Jacques S. Beckmann,Florent Soubrier,Jean Sassard +9 more
TL;DR: Findings show that two independent loci influence different haemodynamic components of blood pressure, and that pulse pressure has a specific genetic determination.
Journal ArticleDOI
A gene differentially expressed in the kidney of the spontaneously hypertensive rat cosegregates with increased blood pressure.
Nilesh J. Samani,David Lodwick,Madeleine Vincent,C. Dubay,M.A. Kaiser,M P Kelly,M. Lo,Janet Harris,Jean Sassard,Mark Lathrop +9 more
TL;DR: It is demonstrated that a recently identified gene of yet unknown function, termed SA, cosegregates with an increase in blood pressure in F2 rats derived from a cross of the spontaneously hypertensive rat with normotensive Wistar-Kyoto rats, providing strong evidence for a primary genetic involvement of the kidney in hypertension.