C. Edouard

TL;DR: Serum BGP appears to be a specific marker for bone formation and can predict the histological profile in PMO and should be valuable in assessing the effects of treatments that increase bone formation.

TL;DR: Those patients who had the largest increases in 47Ca-kinetic and histomorphometric indices of new bone formation showed the greatest increases in trabecular bone volume, suggesting that treatment with human parathyroid hormone fragment caused a dissociation between formation and resorption rates that was confined to trabECular bone.

TL;DR: The results indicate that CS's induce bone rarefaction mainly by decreasing osteoblastic activity at the cell level, however, the bone loss is probably magnified by secondary hyperparathyroidism which increases the birthrate of basic multicellular bone remodelling units.

TL;DR: The high incidence of osteomalacia in osteosclerotic metastases of prostatic origin appears to be the result of the increase in bone formation induced by prostatic cells, and the unability to satisfy the high calcium demand for new bone.

TL;DR: In invaded areas, no major histomorphometric difference was found between patients receiving chemotherapy and untreated patients, demonstrating that if usual chemotherapies reduce the tumour mass, they do not improve histological bone lesions in areas still invaded by plasma cells.