C
C.G.D. Brown
Researcher at University of Edinburgh
Publications - 46
Citations - 1617
C.G.D. Brown is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Theileria parva & Antigen. The author has an hindex of 25, co-authored 46 publications receiving 1521 citations.
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Journal Article
Theileria annulata and T. parva infect and transform different bovine mononuclear cells.
TL;DR: The results showed that despite the many similarities between Theileria annulata and T. parva, they infected different cells of the immune system.
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Tissue damage in cattle infected with Theileria annulata accompanied by metastasis of cytokine-producing, schizont-infected mononuclear phagocytes.
L.M.G. Forsyth,F.C. Minns,E. Kirvar,Rachel Adamson,F. R. Hall,Steven McOrist,C.G.D. Brown,Patricia M. Preston +7 more
TL;DR: Findings provide new evidence that tropical theileriosis can no longer be viewed as a lymphoproliferative disease resulting from the uncontrolled multiplication and metastasis of lymphoid cells infected with T. annulata schizonts, but is caused by a parasite that lives in, and is disseminated by, cytokine-secreting, proliferating mononuclear phagocytes.
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Detection of Theileria annulata in cattle and vector ticks by PCR using the Tams1 gene sequences
E. Kirvar,T. Ilhan,F. Katzer,P. Hooshmand-Rad,E. Zweygarth,C. Gerstenberg,P. Phipps,C.G.D. Brown +7 more
TL;DR: A Polymerase Chain Reaction (PCR) and Southern blot hybridization for the detection of Theileria annulata and the sensitivity and specificity in saponin-extracted DNA samples stored for long periods at −20 °C are described.
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Innate and Adaptive Immune Responses Co-operate to Protect Cattle against Theileria annulata
Patricia M. Preston,F. R. Hall,Elizabeth Glass,J D Campbell,Mohamed Aziz Darghouth,Jabbar S. Ahmed,Brian Shiels,Roger L. Spooner,Frans Jongejan,C.G.D. Brown +9 more
TL;DR: It is now thought that the schizonts of T. annulata inhabit macrophages and B cells, and that tropical theileriosis is not a lymphoproliferative disease.
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Infection of bovine monocyte/macrophage populations with Theileria annulata and Theileria parva
TL;DR: Infection and transformation of cells of the bovine immune system by Theileria annulata and T. parva were compared and it was suggested that class II expression was necessary for T.annulata infection and not necessary for, though not a barrier to T.Parva infection.