B
Brian Shiels
Researcher at University of Glasgow
Publications - 112
Citations - 4087
Brian Shiels is an academic researcher from University of Glasgow. The author has contributed to research in topics: Theileria & Gene. The author has an hindex of 36, co-authored 107 publications receiving 3738 citations. Previous affiliations of Brian Shiels include University of Edinburgh & Scripps Health.
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Journal ArticleDOI
Genome of the host-cell transforming parasite Theileria annulata compared with T. parva.
Arnab Pain,Hubert Renauld,Matthew Berriman,Lee Murphy,Corin Yeats,William Weir,Arnaud Kerhornou,Martin Aslett,Richard P. Bishop,Christiane Bouchier,Madeleine Cochet,Richard M.R. Coulson,Ann Cronin,Etienne P. de Villiers,Audrey Fraser,Nigel Fosker,Malcolm J. Gardner,Arlette Goble,Sam Griffiths-Jones,David Harris,Frank Katzer,Natasha Larke,Angela Lord,Pascal Mäser,Sue McKellar,P. Mooney,Fraser R. Morton,Vishvanath Nene,Susan O'Neil,Claire Price,Michael A. Quail,Ester Rabbinowitsch,Neil D. Rawlings,Simon Rutter,David L. Saunders,Kathy Seeger,Trushar Shah,R. Squares,S. Squares,Adrian Tivey,Alan R. Walker,John Woodward,Dirk A. E. Dobbelaere,Gordon Langsley,Marie Adele Rajandream,Declan J. McKeever,Brian Shiels,Andrew Tait,Bart Barrell,Neil Hall +49 more
TL;DR: The genome of T. annulata is sequenced and the analysis reveals unequally expanded gene families and species-specific genes, and divergent families of putative secreted polypeptides that may reduce immune recognition.
Journal ArticleDOI
Sequence of rat liver alpha 2-macroglobulin and acute phase control of its messenger RNA.
M R Gehring,Brian Shiels,Wolfgang Northemann,M. H. L. De Bruijn,Chen-Chen Kan,A. C. Chain,D. J. Noonan,Georg H. Fey +7 more
TL;DR: The results suggest that the accummulation of alpha 2M mRNA is due to the combined effects of increased transcription rates and post-transcriptional processing.
Journal Article
Simplified northern blot hybridization using 5% sodium dodecyl sulfate.
TL;DR: This procedure eliminates the need for many reagents commonly used in RNA Hybridization and replaces them with two buffers containing 5% sodium dodecyl sulfate for pre-hybridization, hybridization and all post-hybrids washes.
Journal ArticleDOI
Hijacking of host cell IKK signalosomes by the transforming parasite Theileria
Volker Heussler,Sven Rottenberg,Rebekka Schwab,Peter Küenzi,Paula C. Fernandez,Susan McKellar,Brian Shiels,Zhijian J. Chen,Kim Orth,David Wallach,Dirk A. E. Dobbelaere +10 more
TL;DR: This work found that survival of Theileria-transformed leukocytes depends strictly on constitutive nuclear factor kappa B activity and found that this was mediated by recruitment of the multisubunit IκB kinase into large, activated foci on the parasite surface.
Journal ArticleDOI
Development of a multiplex PCR assay for simultaneous detection of Theileria annulata, Babesia bovis and Anaplasma marginale in cattle.
Hüseyin Bilgin Bilgiç,Tülin Karagenç,Martin Simuunza,Brian Shiels,Andy Tait,Hasan Eren,William Weir +6 more
TL;DR: A novel multiplex PCR for Theileria annulata, Babesia bovis and Anaplasma marginale which has been validated using field samples and can be applied to epidemiological studies.