C. Geoffroy-Siraudin

TL;DR: The results clearly indicate that the quality of semen decreased in this population over the study period and the same trends of sperm quality deterioration with time were observed.

TL;DR: This study shows that Cr(VI) is toxic for meiotic cells even at low concentrations, and its toxicity increases in a dose-dependent manner.

TL;DR: The low level of limited asynapsis, the normal H2AX staining and the incomplete loss of germ cells at the pachytene checkpoint indicate that the AZFc region is not critical for meiotic recombination, and it is suggested that the pachedtene phenotype develops secondarily to a primary defect that influences meiosis.

TL;DR: Results show that Cd induces dose-and-time-dependent alterations of the meiotic process of spermatogenesis ex-vivo, and that the lowest metal concentration, which induces an adverse effect, may vary with the cell parameter studied.

TL;DR: Notre laboratoire a developpe des systemes de culture des cellules germinales mâles, en chambre bicamerale, qui reproduisent une barriere hematotesticulaire and permettent d’etudier le mecanisme d“action des regulateurs physiologiques et les effets d”une substance toxique sur la spermatogenese, tout en reduisant le