C
C Gicquel
Researcher at French Institute of Health and Medical Research
Publications - 37
Citations - 3382
C Gicquel is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Genomic imprinting & Beckwith–Wiedemann syndrome. The author has an hindex of 26, co-authored 37 publications receiving 3239 citations. Previous affiliations of C Gicquel include Necker-Enfants Malades Hospital & Pierre-and-Marie-Curie University.
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Journal ArticleDOI
In Vitro Fertilization May Increase the Risk of Beckwith-Wiedemann Syndrome Related to the Abnormal Imprinting of the KCNQ1OT Gene
TL;DR: The department is a reference center in France for molecular diagnosis of BWS, and patients are referred from various medical departments (neonatology, pediatrics, genetics, and fetopathology), and a series of 149 patients referred for overgrowth syndromes were studied.
Journal ArticleDOI
Epimutation of the telomeric imprinting center region on chromosome 11p15 in Silver-Russell syndrome
C Gicquel,Sylvie Rossignol,Sylvie Cabrol,Muriel Houang,Virginie Steunou,Véronique Barbu,Fabienne Danton,Nathalie Thibaud,Martine Le Merrer,Lydie Burglen,Anne-Marie Bertrand,Irène Netchine,Yves Le Bouc +12 more
TL;DR: Findings provide new insight into the pathogenesis of SRS and strongly suggest that the 11p15 imprinted region, in addition to those of 7p11.2-p13 and 7q31-qter, is involved in SRS.
Journal ArticleDOI
11p15 imprinting center region 1 loss of methylation is a common and specific cause of typical Russell-Silver syndrome: clinical scoring system and epigenetic-phenotypic correlations.
Irène Netchine,Irène Netchine,Sylvie Rossignol,Sylvie Rossignol,Marie-Noëlle Dufourg,Marie-Noëlle Dufourg,Salah Azzi,Salah Azzi,Alexandra Rousseau,Laurence Perin,Muriel Houang,Virginie Steunou,Blandine Esteva,Nathalie Thibaud,Marie-Charles Raux M.-C.R. Demay,Fabienne Danton,Elżbieta Petriczko,Anne-Marie Bertrand,Claudine Heinrichs,Jean-Claude Carel,Guy-André Loeuille,Graziella Pinto,Marie-Line Jacquemont,C Gicquel,C Gicquel,S Cabrol,Yves Le Bouc,Yves Le Bouc +27 more
TL;DR: The 11p15 ICR1 epimutation is a major, specific cause of RSS exhibiting failure to thrive, and a clinical scoring system is proposed (including a BMI < -2 SDS), highly predictive of 11p 15 I CR1 LOM, for the diagnosis of RSS.
Journal ArticleDOI
The epigenetic imprinting defect of patients with Beckwith—Wiedemann syndrome born after assisted reproductive technology is not restricted to the 11p15 region
Sylvie Rossignol,Virginie Steunou,Céline Chalas,Antoine Kerjean,M Rigolet,E Viegas-Pequignot,Pierre Jouannet,Y. Le Bouc,C Gicquel +8 more
TL;DR: The mosaic distribution of epimutations suggests that imprinting is lost after fertilisation owing to a failure to maintain methylation marks during pre-implantation development.
Journal ArticleDOI
Rearrangements at the 11p15 locus and overexpression of insulin-like growth factor-II gene in sporadic adrenocortical tumors
C Gicquel,Xavier Bertagna,H Schneid,M Francillard-Leblond,Jean-Pierre Luton,François Girard,Y. Le Bouc +6 more
TL;DR: Results in combination with evidence for overexpression of IGF-II from the 11p15.5 locus suggest that abnormalities in structure and/or expression of the IGF- II gene play a role as a late event of a multistep process of tumorigenesis.