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C. Joel Funk
Researcher at United States Department of Agriculture
Publications - 12
Citations - 1349
C. Joel Funk is an academic researcher from United States Department of Agriculture. The author has contributed to research in topics: Innate immune system & Cellular differentiation. The author has an hindex of 10, co-authored 12 publications receiving 1203 citations. Previous affiliations of C. Joel Funk include Agricultural Research Service.
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Journal ArticleDOI
Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages.
Mihea G Netea,Mihea G Netea,Claudia A. Nold-Petry,Marcel F. Nold,Leo A. B. Joosten,Bastian Opitz,Jonathan H M van der Meer,Frank L. van de Veerdonk,Gerben Ferwerda,Bas Heinhuis,Isabel Devesa,C. Joel Funk,Robert J. Mason,Bart Jan Kullberg,Anna Rubartelli,Jos W. M. van der Meer,Charles A. Dinarello +16 more
TL;DR: It is demonstrated that human blood monocytes release processed IL-1beta after a one-time stimulation with either TLR2 or TLR4 ligands, resulting from constitutively activated caspase-1 and release of endogenous adenosine triphosphate.
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Differentiated Human Alveolar Type II Cells Secrete Antiviral IL-29 (IFN-λ1) in Response to Influenza A Infection
Jieru Wang,Rebecca E. Oberley-Deegan,Shuanglin Wang,Mrinalini P. Nikrad,C. Joel Funk,Kevan L. Hartshorn,Robert J. Mason +6 more
TL;DR: The results suggest that IL-29 exerts IFN-β-independent protection in type II cells through direct activation of antiviral genes during IAV infection.
Journal ArticleDOI
SARS-CoV replicates in primary human alveolar type II cell cultures but not in type I-like cells.
Eric C. Mossel,Jieru Wang,Scott A. Jeffers,Karen E. Edeen,Shuanglin Wang,Gregory P. Cosgrove,C. Joel Funk,Rizwan Manzer,Tanya A. Miura,L. D. Pearson,Kathryn V. Holmes,Robert J. Mason +11 more
TL;DR: In this paper, the authors isolated human alveolar type II cells and maintained them in a highly differentiated state, which supported SARS-CoV replication as evidenced by RT-PCR detection of viral subgenomic RNA and an increase in virus titer.
Journal ArticleDOI
Differentiated Human Alveolar Epithelial Cells and Reversibility of their Phenotype In Vitro
Jieru Wang,Karen E. Edeen,Rizwan Manzer,Yongsheng Chang,Shuanglin Wang,Xueni Chen,C. Joel Funk,Gregory P. Cosgrove,Xiaohui Fang,Robert J. Mason +9 more
TL;DR: This work used a published method for type II cell isolation and developed primary culture systems for maintenance of differentiated adult human alveolar epithelial cells for in vitro studies to study the expression of the phenotypes.
Journal ArticleDOI
Infection of human alveolar macrophages by human coronavirus strain 229E.
C. Joel Funk,Jieru Wang,Yoko Ito,Emily A. Travanty,Dennis R. Voelker,Kathryn V. Holmes,Robert J. Mason +6 more
TL;DR: AMs are an important target for HCoV-229E, and they can mount a pro-inflammatory innate immune response to infection.