R
Rebecca E. Oberley-Deegan
Researcher at National Jewish Health
Publications - 10
Citations - 336
Rebecca E. Oberley-Deegan is an academic researcher from National Jewish Health. The author has contributed to research in topics: Superoxide dismutase & Virus. The author has an hindex of 6, co-authored 10 publications receiving 297 citations. Previous affiliations of Rebecca E. Oberley-Deegan include University of Colorado Denver & University of Nebraska–Lincoln.
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Journal ArticleDOI
Differentiated Human Alveolar Type II Cells Secrete Antiviral IL-29 (IFN-λ1) in Response to Influenza A Infection
Jieru Wang,Rebecca E. Oberley-Deegan,Shuanglin Wang,Mrinalini P. Nikrad,C. Joel Funk,Kevan L. Hartshorn,Robert J. Mason +6 more
TL;DR: The results suggest that IL-29 exerts IFN-β-independent protection in type II cells through direct activation of antiviral genes during IAV infection.
Journal ArticleDOI
Superoxide Dismutase Mimetic, MnTE-2-PyP, Attenuates Chronic Hypoxia-Induced Pulmonary Hypertension, Pulmonary Vascular Remodeling, and Activation of the NALP3 Inflammasome
Leah R. Villegas,Dylan Kluck,Carlie Field,Rebecca E. Oberley-Deegan,Crystal Woods,Michael E. Yeager,Karim C. El Kasmi,Rashmin C. Savani,Russell P. Bowler,Eva Nozik-Grayck +9 more
TL;DR: This study is the first to demonstrate activation of the NALP3 inflammasome with cleavage of caspase-1 and release of active IL-1 β and IL-18 in chronic hypoxic PH, as well as its attenuation by the SOD mimetic, MnTE-2-PyP.
Journal ArticleDOI
A common polymorphism in extracellular superoxide dismutase affects cardiopulmonary disease risk by altering protein distribution.
John M. Hartney,Timothy Stidham,David A. Goldstrohm,Rebecca E. Oberley-Deegan,Michael R. Weaver,Zuzana Valnickova-Hansen,Carsten Scavenius,Richard K.P. Benninger,Katelyn F. Leahy,Richard J. Johnson,Fabienne Gally,Beata Kosmider,Angela K. Zimmermann,Jan J. Enghild,Eva Nozik-Grayck,Russell P. Bowler +15 more
TL;DR: In this article, a nonsynonomous single-nucleotide polymorphism in extracellular superoxide dismutase (EC-SOD; SOD3 ) leads to an arginine to glycine amino acid substitution at position 213 in the heparin-binding domain.
Journal ArticleDOI
Antioxidant proteins and reactive oxygen species are decreased in a murine epidermal side population with stem cell-like characteristics
Wanakee Carr,Rebecca E. Oberley-Deegan,Yuping Zhang,Christopher C. Oberley,Larry W. Oberley,Martine Dunnwald +5 more
TL;DR: The data indicate ROS and antioxidant levels are decreased in stem-like EpSPs, which exhibited less mitochondrial area, fewer peroxisomes and produced lower levels of ROS than Non-SPs.
Journal ArticleDOI
Mycobacterium tuberculosis increases IP-10 and MIG protein despite inhibition of IP-10 and MIG transcription.
Xiyuan Bai,Kathryn Chmura,Alida R. Ovrutsky,Russell P. Bowler,Robert I. Scheinman,Rebecca E. Oberley-Deegan,Haiying Liu,Shaobin Shang,Diane J. Ordway,Edward D. Chan +9 more
TL;DR: The synergy between MTB and IFNγ in the induction of IP-10 and MIG protein appears to involve novel post-transcriptional events that incorporates non-canonical functions of NFκB and p38(mapk).