C
C. Kuo
Researcher at Chiron Corporation
Publications - 10
Citations - 4656
C. Kuo is an academic researcher from Chiron Corporation. The author has contributed to research in topics: Hepatitis C virus & Antibody. The author has an hindex of 8, co-authored 9 publications receiving 4617 citations.
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Journal ArticleDOI
An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis
George Kuo,Q L Choo,Harvey J. Alter,G.L. Gitnick,Allan G. Redeker,Robert H. Purcell,Tatsuo Miyamura,Jules L. Dienstag,M.J. Alter,Cladd E. Stevens,Gary E. Tegtmeier,Ferruccio Bonino,Massimo Colombo,W.-S. Lee,C. Kuo,K. Berger,Jeffrey R. Shuster,Lacy Rasco Overby,Daniel W. Bradley,Michael Houghton +19 more
TL;DR: Assays of ten blood transfusions in the United States that resulted in chronic NANBH revealed that there was at least one positive blood donor in nine of these cases and that all ten recipients seroconverted during their illnesses.
Journal ArticleDOI
Vaccination of chimpanzees against infection by the hepatitis C virus.
Q L Choo,G. Kuo,Robert Ralston,A J Weiner,David Y. Chien,G Van Nest,Jang Han,Kim Berger,Thudium Kent B,C. Kuo +9 more
TL;DR: Despite the induction of a weak humoral immune response to these viral glycoproteins in experimentally infected chimpanzees, a strong humoralimmune response was obtained in all vaccines.
Journal ArticleDOI
Characterization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia viruses.
Robert Ralston,Thudium Kent B,Kim Berger,C. Kuo,B. Gervase,Johh A. Hall,Mark Selby,G. Kuo,Michael Houghton,Qui-Lim Choo +9 more
TL;DR: It is demonstrated that purified E1-E2 complexes were recognized at high frequency by HCV+ human sera and generated protective immunity in chimpanzees, suggesting that these purified HCV envelope proteins display native HCV epitopes.
Journal ArticleDOI
Expression, identification and subcellular localization of the proteins encoded by the hepatitis C viral genome.
Mark Selby,Qui-Lim Choo,Kim Berger,George Kuo,Edward Glazer,Michael R. Eckart,C. Lee,David Y. Chien,C. Kuo,Michael Houghton +9 more
TL;DR: The full-length coding region and selected domains of the hepatitis C virus (HCV) cDNA in mammalian cells by transfection is expressed and the subcellular localizations of the HCV proteins are defined using indirect immunofluorescence assays.
Journal ArticleDOI
The hepatitis C virus encodes a serine protease involved in processing of the putative nonstructural proteins from the viral polyprotein precursor.
Michael R. Eckart,Mark Selby,Frank Masiarz,C. Lee,Kim Berger,Kevin Crawford,C. Kuo,G. Kuo,Michael Houghton,Qui-Lim Choo +9 more
TL;DR: The HCV NS3-mediated cleavage of the NS3/NS4 junction does not require the upstream NS2 domain and may not occur at dibasic sites, in contrast to the situation for the related flaviviral NS3 proteases.