C
C. Martina Messow
Researcher at Robertson Centre for Biostatistics
Publications - 11
Citations - 412
C. Martina Messow is an academic researcher from Robertson Centre for Biostatistics. The author has contributed to research in topics: Sputum & Asthma. The author has an hindex of 8, co-authored 9 publications receiving 353 citations.
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Journal ArticleDOI
Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: Relationship to disease severity
Rekha Chaudhuri,Charles McSharry,Jeffrey Brady,Iona Donnelly,Christal Grierson,Stephen McGuinness,Lisa Jolly,Christopher J. Weir,C. Martina Messow,Mark Spears,Gino Miele,Karl Nocka,Dan Crowther,Joyce Thompson,M Brannigan,Jane Lafferty,Michael Sproule,William MacNee,Martin Connell,John T. Murchison,Malcolm Shepherd,Giora Feuerstein,Douglas K. Miller,Neil C. Thomson +23 more
TL;DR: In this paper, the authors examined the relationship between disease severity assessed by means of lung function and computed tomography (CT) and induced sputum MMP-12 concentrations and activity in patients with asthma and COPD.
Journal ArticleDOI
Tumour necrosis factor inhibition versus rituximab for patients with rheumatoid arthritis who require biological treatment (ORBIT): an open-label, randomised controlled, non-inferiority, trial.
Duncan Porter,Jurgen van Melckebeke,James Dale,C. Martina Messow,Alex McConnachie,Andrew Walker,Robin Munro,John McLaren,Euan McRorie,Jon Packham,Christopher D. Buckley,John Harvie,Peter C. Taylor,Ernest Choy,Costantino Pitzalis,Iain B. McInnes +15 more
TL;DR: Initial treatment with rituximab is non-inferior to initial TNF inhibitor treatment in patients seropositive for rheumatoid arthritis and naive to treatment with biologicals, and is cost saving over 12 months.
Iconographies supplémentaires de l'article : Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: Relationship to disease severity
Rekha Chaudhuri,Charles McSharry,Jeffrey Brady,Iona Donnelly,Christal Grierson,Stephen McGuinness,Lisa Jolly,Christopher J. Weir,C. Martina Messow,Mark Spears,Gino Miele,Karl Nocka,Dan Crowther,Joyce Thompson,M Brannigan,Jane Lafferty,Michael Sproule,William MacNee,Martin Connell,John T. Murchison,Malcolm Shepherd,Giora Feuerstein,Douglas K. Miller,Neil C. Thomson +23 more
TL;DR: Sputum MMP-12 concentrations and activity in patients with COPD are directly associated with the extent of emphysema measured by means of CT, and this finding supports a role for M MP-12 in the pathogenesis of COPD and might suggest that blocking MMP
Journal ArticleDOI
Chronic cough and sputum production are associated with worse clinical outcomes in stable asthma
Neil C. Thomson,Rekha Chaudhuri,C. Martina Messow,Mark Spears,William MacNee,Martin Connell,John T. Murchison,Michael Sproule,Charles McSharry +8 more
TL;DR: Chronic mucus hypersecretion occurs frequently in adults with stable asthma, particularly in smokers with severe disease and is associated with worse current clinical control in smokers and more exacerbations in never smokers.
Journal ArticleDOI
Low sputum MMP-9/TIMP ratio is associated with airway narrowing in smokers with asthma.
Rekha Chaudhuri,Charles McSharry,Jeffrey Brady,Christal Grierson,C. Martina Messow,Mark Spears,Gino Miele,Karl Nocka,William MacNee,Martin Connell,John T. Murchison,Michael Sproule,Omar Hilmi,Douglas K. Miller,Neil C. Thomson +14 more
TL;DR: The association of a low sputum M MP-9 activity/TIMP-1 ratio with persistent airflow obstruction and reduced CT airway lumen area in smokers with asthma may indicate that an imbalance of MMP-9 and TIMPs contributes to structural changes to the airways in this group.