C
C Nachev
Researcher at Oulu University Hospital
Publications - 16
Citations - 4792
C Nachev is an academic researcher from Oulu University Hospital. The author has contributed to research in topics: Blood pressure & Systolic hypertension. The author has an hindex of 14, co-authored 16 publications receiving 4676 citations.
Papers
More filters
Journal ArticleDOI
Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension *
Jan A. Staessen,Robert Fagard,Lutgarde Thijs,Hilde Celis,G G Arabidze,Willem H. Birkenhäger,Christopher J. Bulpitt,P. W. De Leeuw,Colin T. Dollery,Astrid E. Fletcher,Françoise Forette,Gastone Leonetti,C Nachev,ET O'Brien,Joseph B. Rosenfeld,Jose L. Rodicio,Jaakko Tuomilehto,Alberto Zanchetti +17 more
TL;DR: Among elderly patients with isolated systolic hypertension, antihypertensive drug treatment starting with nitrendipine reduces the rate of cardiovascular complications and may prevent 29 strokes or 53 major cardiovascular endpoints.
Journal ArticleDOI
Systolic blood pressure variability as a risk factor for stroke and cardiovascular mortality in the elderly hypertensive population.
Edward Pringle,Charles Phillips,Lutgarde Thijs,Christopher Davidson,Jan A. Staessen,Peter W. de Leeuw,Matti Jääskivi,C Nachev,Gianfranco Parati,Eoin O'Brien,Jaakko Tuomilehto,John Webster,Christopher J. Bulpitt,Robert Fagard +13 more
TL;DR: In the placebo group, but not the active treatment group, increased night-time systolic blood pressure variability on admission to the Syst-Eur trial was an independent risk factor for stroke during the trial.
Journal ArticleDOI
Predictive value of clinic and ambulatory heart rate for mortality in elderly subjects with systolic hypertension
Paolo Palatini,Lutgarde Thijs,Jan A. Staessen,Robert Fagard,Christopher J. Bulpitt,Denis Clement,Peter W. de Leeuw,Matti Jääskivi,Gastone Leonetti,C Nachev,Eoin O'Brien,Gianfranco Parati,Jose L. Rodicio,E. Roman,C Sarti,Jaakko Tuomilehto +15 more
TL;DR: In untreated older patients with isolated systolic hypertension, a clinic heart rate greater than 79 bpm was a significant predictor of all-cause, cardiovascular, and noncardiovascular mortality.
Journal ArticleDOI
Results of the pilot study for the Hypertension in the Very Elderly Trial.
Christopher J. Bulpitt,Nigel Beckett,Jonathan Cooke,D Dumitrascu,Blas Gil-Extremera,C Nachev,Maria do Carmo Pereira Nunes,Ruth Peters,Jan A. Staessen,Lutgarde Thijs +9 more
TL;DR: The preliminary results support the need for the continuing main HYVET trial and it is possible that treatment of 1000 patients for 1 year may reduce stroke events by 19 (nine non-fatal), but may be associated with 20 extra non-stroke deaths.
Journal ArticleDOI
Effects of immediate versus delayed antihypertensive therapy on outcome in the Systolic Hypertension in Europe Trial
Jan A. Staessen,Lutgarde Thijs,Robert Fagard,Hilde Celis,Willem H. Birkenhäger,Christopher J. Bulpitt,Peter W. de Leeuw,Astrid E. Fletcher,Françoise Forette,Gastone Leonetti,Patricia McCormack,C Nachev,Eoin O'Brien,Jose L. Rodicio,Joseph B. Rosenfeld,Cinzia Sarti,Jaakko Tuomilehto,John Webster,Yair Yodfat,Alberto Zanchetti +19 more
TL;DR: Immediate compared with delayed treatment prevented 17 strokes or 25 major cardiovascular events per 1000 patients followed up for 6 years, underscoring the necessity of early treatment of isolated systolic hypertension.