C.P. Sibley

TL;DR: Immunohistochemistry and Western blot analysis showed that SNAT4 is localized to the microvillous and basal plasma membranes of the syncytiotrophoblast, suggesting a role for this isoform of system A in amino acid transport across the placenta.

TL;DR: The data show disproportionate effects of complete Igf2 ablation on the compartments of the placenta, not seen when the placental‐specific transcript alone is deleted, and although the theoretical diffusing capacity of the Igf1null+/− placentA was reduced relative to control, there was no effect of the complete knockout on permeability surface area available for small hydrophilic tracers.

TL;DR: Data show an increased placental transport of calcium from E17 to E19 in P0 compared to WT, which is suggested to be an adaptation in response to the reduced fetal calcium accumulation earlier in gestation and speculate that the ability of the placenta to adapt its supply capacity according to fetal demand may stretch across other essential nutrients.

TL;DR: It is concluded that AFP transfer in the placenta is asymmetric and that there are two available pathways for AFP transfer: from the fetal circulation into the villous core and across fibrinoid deposits at discontinuities in thevillous syncytiotrophoblast to enter the maternal circulation.

TL;DR: This study provides the first evidence of SNAT4 activity in human placenta and demonstrates the contribution ofSNAT4 to system A‐mediated transport decreases between first trimester and term, leading to speculate that at later stages of gestation SNAT1 and/or SNAT2 are more important for the supply of amino acids required for normal fetal growth.