C
C. V. Lockatell
Researcher at University of Maryland, Baltimore
Publications - 9
Citations - 1554
C. V. Lockatell is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Proteus mirabilis & Mutant. The author has an hindex of 9, co-authored 9 publications receiving 1480 citations.
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Journal ArticleDOI
Pyelonephritogenic Escherichia coli and killing of cultured human renal proximal tubular epithelial cells: role of hemolysin in some strains.
Harry L. T. Mobley,D. M. Green,Anna L. Trifillis,David E. Johnson,G. R. Chippendale,C. V. Lockatell,Bradley D. Jones,John W. Warren +7 more
TL;DR: Pyelonephritogenic E. coli strains are more frequently cytotoxic for a putative target, that is, human renal tubular epithelium, than are fecal isolates, and Hemolysin, in some strains, is apparently responsible for this cytotoxicity.
Journal ArticleDOI
Type 1 fimbriae and extracellular polysaccharides are preeminent uropathogenic Escherichia coli virulence determinants in the murine urinary tract.
Farah K. Bahrani-Mougeot,Eric L. Buckles,C. V. Lockatell,J. R. Hebel,David E. Johnson,Christoph M. Tang,Michael S. Donnenberg +6 more
TL;DR: In this article, the authors used signature-tagged mutagenesis (STM) in an unbiased effort to identify genes that are essential for UPEC survival within the murine urinary tract.
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Isogenic P-fimbrial deletion mutants of pyelonephritogenic Escherichia coli: the role of alpha Gal(1-4) beta Gal binding in virulence of a wild-type strain.
Harry L. T. Mobley,Karen G. Jarvis,J. P. Elwood,D. I. Whittle,C. V. Lockatell,R G Russell,David E. Johnson,Michael S. Donnenberg,John W. Warren +8 more
TL;DR: A double pap‐deletion mutant, UPEC76, confirmed by Southern blotting, was unable to agglutinate human type O erythrocytes or α Gal(1–4)β Gal‐coated latex beads.
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Construction of a urease-negative mutant of Proteus mirabilis: analysis of virulence in a mouse model of ascending urinary tract infection.
TL;DR: A role for urease as a critical virulence determinant for uropathogenic P. mirabilis is demonstrated and confirmed in the CBA mouse model of ascending urinary tract infection.
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Contribution of Proteus mirabilis urease to persistence, urolithiasis, and acute pyelonephritis in a mouse model of ascending urinary tract infection.
TL;DR: The urease of P. mirabilis is a critical virulence determinant for colonization, urolithiasis, and severe acute pyelonephritis in an animal model of ascending urinary tract infection.