D
David E. Johnson
Researcher at United States Department of Veterans Affairs
Publications - 64
Citations - 5635
David E. Johnson is an academic researcher from United States Department of Veterans Affairs. The author has contributed to research in topics: Proteus mirabilis & Escherichia coli. The author has an hindex of 40, co-authored 64 publications receiving 5344 citations. Previous affiliations of David E. Johnson include University of Maryland Marlene and Stewart Greenebaum Cancer Center & Veterans Health Administration.
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Journal ArticleDOI
Pyelonephritogenic Escherichia coli and killing of cultured human renal proximal tubular epithelial cells: role of hemolysin in some strains.
Harry L. T. Mobley,D. M. Green,Anna L. Trifillis,David E. Johnson,G. R. Chippendale,C. V. Lockatell,Bradley D. Jones,John W. Warren +7 more
TL;DR: Pyelonephritogenic E. coli strains are more frequently cytotoxic for a putative target, that is, human renal tubular epithelium, than are fecal isolates, and Hemolysin, in some strains, is apparently responsible for this cytotoxicity.
Journal ArticleDOI
Transcriptome of uropathogenic Escherichia coli during urinary tract infection.
Jennifer A. Snyder,Brian J. Haugen,Eric L. Buckles,C. Virginia Lockatell,David E. Johnson,David E. Johnson,Michael S. Donnenberg,Rodney A. Welch,Harry L. T. Mobley +8 more
TL;DR: This study represents the first assessment of any E. coli pathotype's transcriptome in vivo and provides specific insights into the mechanisms necessary for urinary tract pathogenesis.
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Role of Enterococcus faecalis surface protein Esp in the pathogenesis of ascending urinary tract infection.
Nathan Shankar,C. Virginia Lockatell,Arto S. Baghdayan,Cinthia B. Drachenberg,Michael S. Gilmore,David E. Johnson,David E. Johnson +6 more
TL;DR: Enterococcus faecalis bacteria isolated from patients with bacteremia, endocarditis, and urinary tract infections more frequently express the surface protein Esp than do fecal isolates, and it contributes to colonization and persistence of E. Faecalis at this site.
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Nicotinic Acid Limitation Regulates Silencing of Candida Adhesins During UTI
Renee Domergue,Irene Castaño,Alejandro De Las Peñas,Margaret L. Zupancic,Virginia Lockatell,J. Richard Hebel,David E. Johnson,David E. Johnson,Brendan P. Cormack +8 more
TL;DR: It is shown that normally silent EPA genes are expressed during murine urinary tract infection (UTI) and that the inducing signal is the limitation of nicotinic acid (NA), a precursor of Nicotinamide adenine dinucleotide (NAD+).
Journal ArticleDOI
Type 1 fimbriae and extracellular polysaccharides are preeminent uropathogenic Escherichia coli virulence determinants in the murine urinary tract.
Farah K. Bahrani-Mougeot,Eric L. Buckles,C. V. Lockatell,J. R. Hebel,David E. Johnson,Christoph M. Tang,Michael S. Donnenberg +6 more
TL;DR: In this article, the authors used signature-tagged mutagenesis (STM) in an unbiased effort to identify genes that are essential for UPEC survival within the murine urinary tract.