C
C. van Kooten
Researcher at Leiden University
Publications - 63
Citations - 7011
C. van Kooten is an academic researcher from Leiden University. The author has contributed to research in topics: CD40 & Antigen. The author has an hindex of 30, co-authored 63 publications receiving 6801 citations. Previous affiliations of C. van Kooten include Leiden University Medical Center & Schering-Plough.
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Journal ArticleDOI
Activation of human dendritic cells through CD40 cross-linking.
Christophe Caux,Catherine Massacrier,Béatrice Vanbervliet,Bertrand Dubois,C. van Kooten,Isabelle Durand,Jacques Banchereau +6 more
TL;DR: It is demonstrated that dendritic Langerhans cells (D-Lc) generated by culturing cord blood CD34+ progenitor cells with granulocyte/macrophage colony-stimulating and tumor necrosis factor alpha (TNF-alpha) express functional CD40 at a density higher than that found on B cells.
Journal ArticleDOI
The CD40 Antigen and its Ligand
Jacques Banchereau,F Bazan,D Blanchard,Francine Brière,Jean-Pierre Galizzi,C. van Kooten,Yong-Jun Liu,Françoise Rousset,Sem Saeland +8 more
TL;DR: As other members of the tumor necrosis factor receptor family have been shown to bind several ligands, it is possible that CD40 may bind other ligands that may trigger CD40 on different cell types such as hematopoietic cells or epithelial cells.
Journal ArticleDOI
Generation of memory B cells and plasma cells in vitro
Christophe Arpin,Julie Dechanet,C. van Kooten,P. Merville,Géraldine Grouard,Francine Brière,Jacques Banchereau,Yong-Jun Liu +7 more
TL;DR: Results indicate that CD40 ligand directs the differentiation of germinal center B cells toward memory B cells rather than toward plasma cells.
Journal ArticleDOI
Fas ligation induces apoptosis of CD40-activated human B lymphocytes.
TL;DR: The present results show that engagement of CD40 antigen on B cells induces Fas expression and sensitizes them to Fas-mediated apoptosis, and the delayed functional response to Fas ligation after CD40 activation may represent a way to limit the size of a specific B cell clone that is generated during T-B cell interactions.