C
Caiwei Guo
Researcher at Baylor College of Medicine
Publications - 11
Citations - 515
Caiwei Guo is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Neurofibrillary tangle & Transcriptome. The author has an hindex of 6, co-authored 8 publications receiving 319 citations. Previous affiliations of Caiwei Guo include Baylor University & Massachusetts Eye and Ear Infirmary.
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Journal ArticleDOI
Tau Activates Transposable Elements in Alzheimer's Disease.
Caiwei Guo,Caiwei Guo,Hyun-Hwan Jeong,Hyun-Hwan Jeong,Yi-Chen Hsieh,Yi-Chen Hsieh,Hans-Ulrich Klein,Hans-Ulrich Klein,David A. Bennett,Philip L. De Jager,Philip L. De Jager,Zhandong Liu,Zhandong Liu,Joshua M. Shulman +13 more
TL;DR: The results implicate TE activation and associated genomic instability in Tau-mediated AD mechanisms, including both age- and genotype-dependent activation of TE expression by Tau.
Journal ArticleDOI
Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer's Disease.
Yi-Chen Hsieh,Caiwei Guo,Hari Krishna Yalamanchili,Measho Abreha,Rami Al-Ouran,Yarong Li,Eric B. Dammer,James J. Lah,Allan I. Levey,David A. Bennett,Philip L. De Jager,Philip L. De Jager,Nicholas T. Seyfried,Zhandong Liu,Zhandong Liu,Joshua M. Shulman +15 more
TL;DR: It is shown that loss of function in SmB, encoding a core spliceosomal protein, causes decreased survival, progressive locomotor impairment, and neuronal loss, independent of Tau toxicity, and genetic disruption of these factors enhances Tau-mediated neurodegeneration in AD.
Journal ArticleDOI
Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease
Amit K. Chouhan,Caiwei Guo,Yi-Chen Hsieh,Hui Ye,Mumine Senturk,Zhongyuan Zuo,Yarong Li,Shreyasi Chatterjee,Juan Botas,George R. Jackson,George R. Jackson,George R. Jackson,Hugo J. Bellen,Joshua M. Shulman +13 more
TL;DR: Interestingly, Tau and αSyn each cause prominent but distinct synaptotoxic profiles, including disorganization or enlargement of photoreceptor terminals, respectively, which highlight variable and dynamic properties of neurodegeneration triggered by these disease-relevant proteins in vivo.
Proceedings ArticleDOI
An ultra-fast and scalable quantification pipeline for transposable elements from next generation sequencing data.
TL;DR: SalmonTE, a fast and reliable pipeline for the quantification of TEs from RNA-seq data, is developed and benchmarked against TEtranscripts, a widely used TE quantification method, and three other quantification methods using several RNA- sequencing datasets from Drosophila melanogaster and human cell-line.
Journal ArticleDOI
Integrated analysis of the aging brain transcriptome and proteome in tauopathy
Carl Grant Mangleburg,Timothy Wu,Hari Krishna Yalamanchili,Caiwei Guo,Yi-Chen Hsieh,Duc M. Duong,Eric B. Dammer,Philip L. De Jager,Philip L. De Jager,Nicholas T. Seyfried,Zhandong Liu,Zhandong Liu,Joshua M. Shulman +12 more
TL;DR: The results comprise a powerful, cross-species functional genomics resource for tauopathy, revealing Tau-mediated disruption of gene expression, including dynamic, age-dependent interactions between the brain transcriptome and proteome.