Z
Zhandong Liu
Researcher at Baylor College of Medicine
Publications - 135
Citations - 6149
Zhandong Liu is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Graphical model & Neurodegeneration. The author has an hindex of 37, co-authored 135 publications receiving 4196 citations. Previous affiliations of Zhandong Liu include Howard Hughes Medical Institute & Rice University.
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Journal ArticleDOI
Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia
Jiangbin Ye,Jing Fan,Sriram Venneti,Ying Wooi Wan,Bruce R. Pawel,Ji Zhang,Lydia W.S. Finley,Chao Lu,Tullia Lindsten,Justin R. Cross,Guoliang Qing,Zhandong Liu,M. Celeste Simon,Joshua D. Rabinowitz,Craig B. Thompson +14 more
TL;DR: It is demonstrated that the serine catabolic enzyme SHMT2 is induced upon hypoxic stress and is critical for maintaining NADPH production and redox balance to support tumor cell survival and growth.
Journal ArticleDOI
A Drosophila Genetic Resource of Mutants to Study Mechanisms Underlying Human Genetic Diseases
Shinya Yamamoto,Manish Jaiswal,Wu Lin Charng,Tomasz Gambin,Ender Karaca,Ghayda M. Mirzaa,Ghayda M. Mirzaa,Wojciech Wiszniewski,Hector Sandoval,Nele A Haelterman,Bo Xiong,Ke Zhang,Vafa Bayat,Gabriela David,Tongchao Li,Kuchuan Chen,Upasana Gala,Tamar Harel,Davut Pehlivan,Samantha Penney,Lisenka E.L.M. Vissers,Joep de Ligt,Shalini N. Jhangiani,Yajing Xie,Stephen H. Tsang,Yesim Parman,Merve Sivaci,Esra Battaloglu,Donna M. Muzny,Ying Wooi Wan,Zhandong Liu,Alexander T. Lin-Moore,Robin D. Clark,Cynthia J. Curry,Nichole Link,Karen L. Schulze,Eric Boerwinkle,William B. Dobyns,William B. Dobyns,Rando Allikmets,Richard A. Gibbs,Rui Chen,James R. Lupski,Michael F. Wangler,Hugo J. Bellen +44 more
TL;DR: A mosaic genetic screen of lethal mutations on the Drosophila X chromosome is conducted to identify genes required for the development, function, and maintenance of the nervous system and to provide insights into microcephaly associated with brain dysgenesis.
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Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease
Alexandra Litvinchuk,Ying Wooi Wan,Dan B. Swartzlander,Fading Chen,Allysa L. Cole,Nicholas E. Propson,Qian Wang,Bin Zhang,Zhandong Liu,Hui Zheng +9 more
TL;DR: It is shown that the expression of C3 and C3a receptor (C3aR1) are positively correlated with cognitive decline and Braak staging in human AD brains and a crucial role for activation of the C3-C3 aR network in mediating neuroinflammation and tau pathology is demonstrated.
Journal ArticleDOI
Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease
Ethan R. Roy,Baiping Wang,Ying-Wooi Wan,Gabriel Chiu,Allysa L. Cole,Zhuoran Yin,Nicholas E. Propson,Yin Xu,Joanna L. Jankowsky,Zhandong Liu,Virginia M.-Y. Lee,John Q. Trojanowski,Stephen D. Ginsberg,Oleg Butovsky,Hui Zheng,Wei Cao +15 more
TL;DR: Gene expression interrogation revealed that IFN pathway was grossly upregulated in clinical AD and significantly correlated with disease severity and complement activation, therefore, IFN constitutes a pivotal element within the neuroinflammatory network of AD and critically contributes to neuropathogenic processes.
Journal ArticleDOI
Digital sorting of complex tissues for cell type-specific gene expression profiles
TL;DR: A Digital Sorting Algorithm for extracting cell-type specific gene expression profiles from mixed tissue samples that is unbiased and does not require prior knowledge of cell type frequencies is described.