C
Camilo Rojas
Researcher at Johns Hopkins University
Publications - 102
Citations - 5135
Camilo Rojas is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Glutamate carboxypeptidase II & Glutamate receptor. The author has an hindex of 35, co-authored 99 publications receiving 4396 citations. Previous affiliations of Camilo Rojas include Eisai & Chiba University.
Papers
More filters
Journal ArticleDOI
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.
Meghan J. Seltzer,Bryson D. Bennett,Avadhut D. Joshi,Ping Gao,Ajit G. Thomas,Dana Ferraris,Takashi Tsukamoto,Camilo Rojas,Barbara S. Slusher,Joshua D. Rabinowitz,Chi V. Dang,Gregory J. Riggins +11 more
TL;DR: The ability to selectively slow growth in cells with IDH1 mutations by inhibiting glutaminase suggests a unique reprogramming of intermediary metabolism and a potential therapeutic strategy.
Journal ArticleDOI
Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)
Mary M. Robinson,Steven J. McBryant,Takashi Tsukamoto,Camilo Rojas,Dana Ferraris,Sean K. Hamilton,Jeffrey C. Hansen,Norman P. Curthoys +7 more
TL;DR: BPTES is a unique and potent inhibitor of rat KGA and elucidates a novel mechanism of inactivation, which established that BPTES prevents the formation of large phosphate-induced oligomers and instead promotes theformation of a single oligomeric species with distinct physical properties.
Journal ArticleDOI
Biodistribution, Tumor Detection, and Radiation Dosimetry of 18F-DCFBC, a Low-Molecular-Weight Inhibitor of Prostate-Specific Membrane Antigen, in Patients with Metastatic Prostate Cancer
Steve Y. Cho,Kenneth L. Gage,Ronnie C. Mease,Srinivasan Senthamizhchelvan,Daniel P. Holt,Akimosa Jeffrey-Kwanisai,Christopher J. Endres,Robert F. Dannals,George Sgouros,Martin A. Lodge,Mario A. Eisenberger,Ronald Rodriguez,Michael A. Carducci,Camilo Rojas,Barbara S. Slusher,Alan P. Kozikowski,Martin G. Pomper +16 more
TL;DR: The findings demonstrate the potential of 18F-DCFBC as a new positron-emitting imaging agent for the detection of metastatic PCa and provides dose estimates that are comparable to those of other PET radiopharmaceuticals such as 18F -FDG.
Journal ArticleDOI
Palonosetron exhibits unique molecular interactions with the 5-HT3 receptor.
Camilo Rojas,Marigo Stathis,Ajit G. Thomas,Edward B. Massuda,Jesse Alt,Jie Zhang,Ed Rubenstein,Silvia Sebastiani,Sergio Cantoreggi,Solomon H. Snyder,Barbara S. Slusher +10 more
TL;DR: This is the first report showing palonosetron's interaction with the 5-HT3 receptor at the molecular level, clearly differentiating it from other 5- HT3-RAs.
Journal ArticleDOI
Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.
Krupa Shukla,Dana Ferraris,Ajit G. Thomas,Marigo Stathis,Bridget Duvall,Greg Delahanty,Jesse Alt,Rana Rais,Camilo Rojas,Ping Gao,Yan Xiang,Chi V. Dang,Barbara S. Slusher,Takashi Tsukamoto +13 more
TL;DR: In an attempt to identify more potent GLS inhibitors with improved drug-like molecular properties, a series of BPTES analogs were synthesized and evaluated and revealed that some truncated analogs retained the potency of B PTES, presenting an opportunity to improve its aqueous solubility.