A
Ajit G. Thomas
Researcher at Johns Hopkins University
Publications - 89
Citations - 4957
Ajit G. Thomas is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Glutamate receptor & Glutamate carboxypeptidase II. The author has an hindex of 28, co-authored 74 publications receiving 3822 citations. Previous affiliations of Ajit G. Thomas include Johns Hopkins University School of Medicine & Chiba University.
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Journal ArticleDOI
Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
Scott J. Dixon,Darpan N Patel,Matthew Welsch,Rachid Skouta,Eric D Lee,Miki Hayano,Ajit G. Thomas,Caroline E Gleason,Nicholas P. Tatonetti,Barbara S. Slusher,Brent R. Stockwell +10 more
TL;DR: Dixon, Patel, et al. as mentioned in this paper found that erastin is a very effective inhibitor of system xc− function and that it is over 1000 times more potent than the previously known best inhibitor, sulfasalazine.
Journal ArticleDOI
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.
Meghan J. Seltzer,Bryson D. Bennett,Avadhut D. Joshi,Ping Gao,Ajit G. Thomas,Dana Ferraris,Takashi Tsukamoto,Camilo Rojas,Barbara S. Slusher,Joshua D. Rabinowitz,Chi V. Dang,Gregory J. Riggins +11 more
TL;DR: The ability to selectively slow growth in cells with IDH1 mutations by inhibiting glutaminase suggests a unique reprogramming of intermediary metabolism and a potential therapeutic strategy.
Journal ArticleDOI
Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis
Yan Xiang,Zachary E. Stine,Jinsong Xia,Yunqi Lu,Roddy S. O’Connor,Brian J. Altman,Annie L. Hsieh,Arvin M. Gouw,Ajit G. Thomas,Ping Gao,Linchong Sun,Libing Song,Benedict Yan,Barbara S. Slusher,Jingli Zhuo,London L.P.J. Ooi,Caroline G.L. Lee,Caroline G.L. Lee,Anthony A. Mancuso,Andrew S. McCallion,Anne Le,Michael C. Milone,Stephen Rayport,Dean W. Felsher,Chi V. Dang +24 more
TL;DR: It is reported that loss of one copy of Gls blunted tumor progression in an immune-competent MYC-mediated mouse model of hepatocellular carcinoma and small molecule and genetic inhibition of GLS are supported for targeting the tumor cell-autonomous dependence on GLS for cancer therapy.
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Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury.
Barbara S. Slusher,James J. Vornov,Ajit G. Thomas,Patricia D. Hurn,Izumi Harukuni,Anish Bhardwaj,Richard J. Traystman,Michael B. Robinson,Paul Britton,X.-C. May Lu,Frank C. Tortella,Krystyna M. Wozniak,Marc Yudkoff,Beth M. Potter,Paul F. Jackson +14 more
TL;DR: It is demonstrated that the newly described 2-PMPA (2-(phosphonomethyl)pentanedioic acid) robustly protects against ischemic injury in a neuronal culture model of stroke and in rats after transient middle cerebral artery occlusion, indicating that NAALADase inhibition may have use in neurological disorders in which excessive excitatory amino acid transmission is pathogenic.
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Palonosetron exhibits unique molecular interactions with the 5-HT3 receptor.
Camilo Rojas,Marigo Stathis,Ajit G. Thomas,Edward B. Massuda,Jesse Alt,Jie Zhang,Ed Rubenstein,Silvia Sebastiani,Sergio Cantoreggi,Solomon H. Snyder,Barbara S. Slusher +10 more
TL;DR: This is the first report showing palonosetron's interaction with the 5-HT3 receptor at the molecular level, clearly differentiating it from other 5- HT3-RAs.