C
Carl E. Mcintosh
Researcher at National Institutes of Health
Publications - 25
Citations - 4090
Carl E. Mcintosh is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Population & Transcription (biology). The author has an hindex of 17, co-authored 25 publications receiving 3872 citations. Previous affiliations of Carl E. Mcintosh include Smithsonian Institution & National Museum of Natural History.
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The simple fool's guide to PCR
Bailey Kessing,Henrietta B. Croom,Andrew P. Martin,Carl E. Mcintosh,W. Owen McMillan,Stephen R. Palumbi +5 more
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Evolution on a volcanic conveyor belt: using phylogeographic reconstructions and K-Ar-based ages of the Hawaiian Islands to estimate molecular evolutionary rates.
TL;DR: K–Ar estimates of the date of an island’s formation provide a maximum age for the taxa inhabiting the island and can be used to calibrate rates of molecular change under the following assumptions: (i) K–Ar dates are accurate; (ii) tree topologies show that derivation of taxa parallels the timing of island formation;
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A noninvasive method for distinguishing among canid species: amplification and enzyme restriction of DNA from dung
TL;DR: To detect and study the endangered kit fox, mitochondrial DNA markers that can be amplified from small amounts of DNA extracted from scats are developed that discriminated among all five canid species and correctly identified 10 ‘unknown’ fox scats to species in blind tests.
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The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve the HLA Class I Antigen Recognition Groove
Minzhong Tang,James A. Lautenberger,Xiaojiang Gao,Xiaojiang Gao,Efe Sezgin,Sher L. Hendrickson,Jennifer L. Troyer,Victor A. David,Li Guan,Carl E. Mcintosh,Xiuchan Guo,Xiuchan Guo,Yuming Zheng,Jian Liao,Hong Deng,Michael Malasky,Bailey Kessing,Cheryl A. Winkler,Mary Carrington,Yi Zeng,Yi Zeng,Stephen J. O'Brien +21 more
TL;DR: Nasopharyngeal carcinoma resistance alleles carrying the strongly associated amino acid variants implicate specific class I peptide recognition motifs in HLA-A and -B peptide binding groove as conferring strong genetic influence on the development of NPC in China.
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Natural selection of the major histocompatibility complex (Mhc) in Hawaiian honeycreepers (Drepanidinae).
TL;DR: The notion that balancing selection operates at the Mhc in the honeycreepers is supported by transpecies polymorphism and strikingly high dN/dS ratios at codons putatively involved in peptide interaction.