C
Carl-Gerhard Gottfries
Researcher at University of Gothenburg
Publications - 118
Citations - 5384
Carl-Gerhard Gottfries is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Dementia & Chronic fatigue syndrome. The author has an hindex of 40, co-authored 118 publications receiving 5165 citations. Previous affiliations of Carl-Gerhard Gottfries include Umeå University & Sahlgrenska University Hospital.
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The clinical efficacy of citalopram in treatment of emotional disturbances in dementia disorders. A Nordic multicentre study.
TL;DR: None of the changes observed during the double-blind withdrawal period were identified as withdrawal symptoms or rebound phenomena and citalopram provoked few and comparatively mild side-effects.
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Membrane Lipids, Selectively Diminished in Alzheimer Brains, Suggest Synapse Loss as a Primary Event in Early‐Onset Form (Type I) and Demyelination in Late‐Onset Form (Type II)
TL;DR: The characteristic membrane lipid disturbance in AD type II was a loss of myelin lipids, the first time a fundamental biochemical difference has been shown between the two major forms of AD.
Journal ArticleDOI
Biochemical changes in dementia disorders of Alzheimer type (AD/SDAT).
Carl-Gerhard Gottfries,Rolf Adolfsson,Sten-Magnus Aquilonius,Avid Carlsson,Sven-Åke Eckernäs,Agneta Nordberg,Lars Oreland,Lars Svennerholm,Å. Wiberg,Bengt Winblad +9 more
TL;DR: In postmortem investigations of patients with dementia of Alzheimer type (AD/SDAT) the brain weight was significantly reduced when compared to controls and the activity of monoamine oxidase B was increased suggesting a proliferation of extra neuronal tissue in the AD/ SDAT-brains.
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A controlled multicenter clinical study of citalopram and placebo in elderly depressed patients with and without concomitant dementia.
A. L. Nyth,Carl-Gerhard Gottfries,K. Lyby,L. Smedegaard-Andersen,J. Gylding-Sabroe,M. Kristensen,H.-E. Refsum,E. Öfsti,S. Eriksson,S. Syversen +9 more
TL;DR: Results of ratings on the Gottfries‐Bråne‐Steen dementia rating scale indicated that both cognitive and emotional functioning improved significantly more in the citalopram‐ treated subgroup of patients with dementia than in the placebo‐treated subgroup.
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Determination of monoamine and monoamine metabolites in the human brain: post mortem studies in a group of suicides and in a control group.
TL;DR: Different nuclei and regions of the brain from patients who had committed suicide and from controls were analysed for their content of monoamine and monoamine metabolites.