C
Carl P. LeBel
Researcher at University of California, Irvine
Publications - 13
Citations - 4200
Carl P. LeBel is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Oxidative stress & Reactive oxygen species. The author has an hindex of 12, co-authored 13 publications receiving 3988 citations. Previous affiliations of Carl P. LeBel include Arthur D. Little & Alkermes.
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Journal ArticleDOI
Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress.
TL;DR: Data suggest that H2O2-Fe(2+)-derived oxidant is mainly responsible for the nonenzymatic oxidation of DCFH, which remains an attractive probe as an overall index of oxidative stress in toxicological phenomena.
Journal Article
Reactive oxygen species formation as a biomarker of methylmercury and trimethyltin neurotoxicity.
TL;DR: The results demonstrate that DCF fluorescence provides a good measure of overall ROS formation in synaptosomes of both in vitro as well as in vivo systems, and support that oxidative damage may be the primary mechanism underlying the neurotoxicity induced by these organometals.
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Sensitive and rapid quantitation of oxygen reactive species formation in rat synaptosomes.
Carl P. LeBel,Stephen C. Bondy +1 more
TL;DR: Results indicate that DCF fluorescence is a sensitive, quantitative and direct measure of oxygen reactive species formation in synaptosomes, providing a rapid method for investigating early neuronal events that occur during oxidative stress.
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Organometal-induced increases in oxygen reactive species: The potential of 2′,7′-dichlorofluorescin diacetate as an index of neurotoxic damage
TL;DR: The data demonstrate that oxygen reactive species are elevated in brain regions, cerebellum (MeHg) and hippocampus, believed to be selectively vulnerable to these toxic agents, and suggest that oxidative damage may be a mechanism underlying the toxicity of both organometals.
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The relationship between excitotoxicity and oxidative stress in the central nervous system
Stephen C. Bondy,Carl P. LeBel +1 more
TL;DR: Potential mechanisms which may unit hyperexcitation to the excessive generation of reactive oxygen species and the degree of linkage between these events appears rather strong are delineated.