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Harry Ischiropoulos

Researcher at Children's Hospital of Philadelphia

Publications -  247
Citations -  47770

Harry Ischiropoulos is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Nitric oxide & Peroxynitrite. The author has an hindex of 90, co-authored 242 publications receiving 44983 citations. Previous affiliations of Harry Ischiropoulos include Fujita Health University & Rowan University.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress.

Carl P. LeBel, +2 more
- 01 Mar 1992 - 
TL;DR: Data suggest that H2O2-Fe(2+)-derived oxidant is mainly responsible for the nonenzymatic oxidation of DCFH, which remains an attractive probe as an overall index of oxidative stress in toxicological phenomena.
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Peroxynitrite: biochemistry, pathophysiology and development of therapeutics

Csaba Szabó, +3 more
- 01 Aug 2007 - 
TL;DR: This Review focuses on pharmacological strategies to attenuate the toxic effects of peroxynitrite, which include its catalytic reduction to nitrite and its isomerization to nitrate by metalloporphyrins, which have led to potential candidates for drug development for cardiovascular, inflammatory and neurodegenerative diseases.
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Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

Benoit I. Giasson, +8 more
- 03 Nov 2000 - 
TL;DR: The selective and specific nitration of alpha-synuclein in these disorders provides evidence to directly link oxidative and nitrative damage to the onset and progression of neurodegenerative synucleinopathies.
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Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

Harry Ischiropoulos, +6 more
- 01 Nov 1992 - 
TL;DR: The mechanism appears to involve peroxynitrite initially reacting with the active site copper to form an intermediate with the reactivity of nitronium ion (NO2+), which then nitrates tyrosine on a second molecule of superoxide dismutase.