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Carla Cugini
Researcher at Rutgers University
Publications - 25
Citations - 1069
Carla Cugini is an academic researcher from Rutgers University. The author has contributed to research in topics: Borrelia burgdorferi & Porphyromonas gingivalis. The author has an hindex of 13, co-authored 23 publications receiving 867 citations. Previous affiliations of Carla Cugini include Harvard University & Tufts Medical Center.
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Journal ArticleDOI
Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa
Carla Cugini,M. Worth Calfee,John M. Farrow,Diana K. Morales,Everett C. Pesci,Deborah A. Hogan +5 more
TL;DR: It is reported that the addition of farnesol to cultures of Pseudomonas aeruginosa, an opportunistic human bacterial pathogen, leads to decreased production of the PseUDomonas quinolone signal (PQS) and the PQS‐controlled virulence factor, pyocyanin.
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Candida albicans-produced farnesol stimulates Pseudomonas quinolone signal production in LasR-defective Pseudomonas aeruginosa strains
TL;DR: It is proposed that ROS are responsible for the activation of downstream portions of this quorum sensing pathway, and farnesol or ROS stimulate virulence factor production in lasR strains provides new insight into the virulence potential of these strains.
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Targeted mutation of the outer membrane protein P66 disrupts attachment of the Lyme disease agent, Borrelia burgdorferi, to integrin αvβ3
Jenifer Coburn,Carla Cugini +1 more
TL;DR: This work describes the first description of the targeted disruption of a candidate B. burgdorferi virulence factor with a known biochemical function that can be quantified, and demonstrates the importance of P66 in the attachment of this pathogenic spirochete to a human cell-surface receptor.
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Borrelia burgdorferi BBB07 Interaction With Integrin α3β1 Stimulates Production of Pro-Inflammatory Mediators in Primary Human Chondrocytes
Aruna K. Behera,Enrique A. Durand,Carla Cugini,Styliani Antonara,Lori Bourassa,Ethan Hildebrand,Linden T. Hu,Linden T. Hu,Jenifer Coburn,Jenifer Coburn +9 more
TL;DR: A B.’burgdorferi protein is identified, BBB07, that interacts with integrin α3β1 and stimulates production of pro‐inflammatory mediators in primary human chondrocyte cells.
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Porphyromonas gingivalis : keeping the pathos out of the biont
TL;DR: Some of the latest information regarding what is known about the Porphyromonas gingivalis role in periodontitis is summarized, including pathogenic potential as well as ecological and nutritional parameters that may shift this commensal to a virulent state.