Linden T. Hu

TL;DR: This Review integrates a large body of information on the phylogenetic diversity, molecular biology, genetics and host interactions of B. burgdorferi into a cohesive picture of the molecular and cellular events that transpire as Lyme disease spirochaetes transit between their arthropod and vertebrate hosts during the enzootic cycle.

TL;DR: There is considerable impairment of health-related quality of life among patients with persistent symptoms despite previous antibiotic treatment for acute Lyme disease, and treatment with intravenous and oral antibiotics for 90 days did not improve symptoms more than placebo.

TL;DR: Evidence supports the use of US Food and Drug Administration-approved serologic tests, such as an enzyme immunoassay (EIA), followed by Western blot testing, to diagnose extracutaneous manifestations of Lyme disease.

TL;DR: A novel case of septic arthritis of the symphysis pubis due to Streptococcus pneumoniae is reported and antibiotic courses of 6 weeks’ duration are recommended, since osteomyelitis is present in 97% of patients.

TL;DR: Killing growing cultures of B. burgdorferi with antibiotics used to treat the disease was distinctly biphasic, with a small subpopulation of surviving cells, indicating that these are persisters rather than resistant mutants, and pulse dosing an antibiotic to eliminate persisters was examined.