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Carla Inouye
Researcher at University of California, Berkeley
Publications - 36
Citations - 3820
Carla Inouye is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Transcription preinitiation complex & Eukaryotic transcription. The author has an hindex of 27, co-authored 34 publications receiving 3572 citations. Previous affiliations of Carla Inouye include Howard Hughes Medical Institute & University of California, San Diego.
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Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3
TL;DR: The data suggest that YY1 negatively regulates transcription by tethering RPD3 to DNA as a cofactor and that this transcriptional mechanism is highly conserved from yeast to human.
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Diversity of Chlamydia trachomatis major outer membrane protein genes.
TL;DR: Genomic DNA libraries were constructed for Chlamydia trachomatis serovars B and C by using BamHI fragments, and recombinants that contained the major outer membrane protein (omp1) gene for each serovar were identified and sequenced.
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Selectivity of chromatin-remodelling cofactors for ligand-activated transcription.
TL;DR: It is shown that transcriptional activation mediated by nuclear hormone receptors requires TATA-binding protein (TBP)-associated factors (TAFs) as well as the multi-subunit cofactors ARC/CRSP, which demonstrate functional selectivity amongst highly related complexes involved in gene regulation.
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Bromodomains mediate an acetyl-histone encoded antisilencing function at heterochromatin boundaries.
TL;DR: It is shown that yeast Bdf1 bromodomains recognize endogenous acetyl-histone H3/H4 as a mechanism for chromatin association in vivo and suggest an active role for BDF1 in euchromatin maintenance and antisilencing through a histone tail-encoded boundary function.
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Near-atomic resolution visualization of human transcription promoter opening
TL;DR: Cryo-electron microscropy is used to determine near-atomic resolution structures of the human PIC in a closed state, an open state, and an initially transcribing complex, illustrating the sequential conformational changes that accompany the transition from each state to the next throughout the transcription initiation process.