R
Richard S. Stephens
Researcher at University of California, Berkeley
Publications - 97
Citations - 8108
Richard S. Stephens is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Chlamydia trachomatis & Gene. The author has an hindex of 46, co-authored 97 publications receiving 7864 citations. Previous affiliations of Richard S. Stephens include University of California, San Francisco & University of California.
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Journal ArticleDOI
Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatis
Richard S. Stephens,Sue Kalman,Claudia J. Lammel,Jun Fan,Rekha Marathe,L. Aravind,Wayne Mitchell,Lynn Olinger,Roman L. Tatusov,Qixun Zhao,Eugene V. Koonin,Ronald W. Davis +11 more
TL;DR: The phylogenetic mosaic of chlamydial genes, including a large number of genes with phylogenetic origins from eukaryotes, implies a complex evolution for adaptation to obligate intracellular parasitism.
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Comparative genomes of Chlamydia pneumoniae and C. trachomatis.
Sue Kalman,Wayne Mitchell,Wayne Mitchell,Rekha Marathe,Claudia J. Lammel,Jun Fan,Richard W. Hyman,Lynn Olinger,Lynn Olinger,Jane Grimwood,Ronald W. Davis,Richard S. Stephens,Richard S. Stephens +12 more
TL;DR: Analysis of the C. pneumoniae genome revealed 214 protein-coding sequences not found in C. trachomatis, most without homologues to other known sequences, which will provide an understanding of the common biological processes required for infection and survival in mammalian cells.
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Mechanisms of host cell exit by the intracellular bacterium Chlamydia.
TL;DR: Using a GFP-based approach to visualize chlamydial inclusions within cells by live fluorescence videomicroscopy, it is identified that Chlamydia release occurred by two mutually exclusive pathways: lysis and extrusion.
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The cellular paradigm of chlamydial pathogenesis
TL;DR: The inflammatory processes of chlamydial pathogenesis are elicited by infected host cells and are necessary and sufficient to account for chronic and intense inflammation and the promotion of cellular proliferation, tissue remodeling and scarring, the ultimate cause of disease sequelae.
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Diversity of Chlamydia trachomatis major outer membrane protein genes.
TL;DR: Genomic DNA libraries were constructed for Chlamydia trachomatis serovars B and C by using BamHI fragments, and recombinants that contained the major outer membrane protein (omp1) gene for each serovar were identified and sequenced.